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Tytuł:
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Evolution and Diversity of TGF-β Pathways are Linked with Novel Developmental and Behavioral Traits.
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Autorzy:
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Lo WS; Department for Integrative Evolutionary Biology, Max-Planck Institute for Biology Tübingen, Max-Planck Ring 9, 72076 Tübingen, Germany.
Roca M; Max Planck Research Group Genetics of Behavior, Max Planck Institute for Neurobiology of Behavior-Caesar, Ludwig-Erhard-Allee 2, 53175, Bonn, Germany.
Dardiry M; Department for Integrative Evolutionary Biology, Max-Planck Institute for Biology Tübingen, Max-Planck Ring 9, 72076 Tübingen, Germany.
Mackie M; Department of Biology, California State University, Northridge, CA.
Eberhardt G; Department for Integrative Evolutionary Biology, Max-Planck Institute for Biology Tübingen, Max-Planck Ring 9, 72076 Tübingen, Germany.
Witte H; Department for Integrative Evolutionary Biology, Max-Planck Institute for Biology Tübingen, Max-Planck Ring 9, 72076 Tübingen, Germany.
Hong R; Department of Biology, California State University, Northridge, CA.
Sommer RJ; Department for Integrative Evolutionary Biology, Max-Planck Institute for Biology Tübingen, Max-Planck Ring 9, 72076 Tübingen, Germany.
Lightfoot JW; Max Planck Research Group Genetics of Behavior, Max Planck Institute for Neurobiology of Behavior-Caesar, Ludwig-Erhard-Allee 2, 53175, Bonn, Germany.
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Źródło:
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Molecular biology and evolution [Mol Biol Evol] 2022 Dec 05; Vol. 39 (12).
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2003- : New York, NY : Oxford University Press
Original Publication: [Chicago, Ill.] : University of Chicago Press, [c1983-
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MeSH Terms:
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Caenorhabditis elegans Proteins*/genetics
Caenorhabditis elegans Proteins*/metabolism
Rhabditida*/genetics
Rhabditida*/metabolism
Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Gene Regulatory Networks
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Grant Information:
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SC1 GM140970 United States GM NIGMS NIH HHS
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Contributed Indexing:
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Keywords: Caenorhabditis elegans; Pristionchus pacificus; TGF-β signaling; behavior; dauer; developmental systems drift; kin-recognition; phenotypic plasticity; signaling pathway evolution
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Substance Nomenclature:
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0 (Caenorhabditis elegans Proteins)
0 (Transforming Growth Factor beta)
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Entry Date(s):
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Date Created: 20221205 Date Completed: 20221216 Latest Revision: 20231128
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Update Code:
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20240104
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PubMed Central ID:
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PMC9733428
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DOI:
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10.1093/molbev/msac252
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PMID:
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36469861
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Transforming growth factor-β (TGF-β) signaling is essential for numerous biologic functions. It is a highly conserved pathway found in all metazoans including the nematode Caenorhabditis elegans, which has also been pivotal in identifying many components. Utilizing a comparative evolutionary approach, we explored TGF-β signaling in nine nematode species and revealed striking variability in TGF-β gene frequency across the lineage. Of the species analyzed, gene duplications in the DAF-7 pathway appear common with the greatest disparity observed in Pristionchus pacificus. Specifically, multiple paralogues of daf-3, daf-4 and daf-7 were detected. To investigate this additional diversity, we induced mutations in 22 TGF-β components and generated corresponding double, triple, and quadruple mutants revealing both conservation and diversification in function. Although the DBL-1 pathway regulating body morphology appears highly conserved, the DAF-7 pathway exhibits functional divergence, notably in some aspects of dauer formation. Furthermore, the formation of the phenotypically plastic mouth in P. pacificus is partially influenced through TGF-β with the strongest effect in Ppa-tag-68. This appears important for numerous processes in P. pacificus but has no known function in C. elegans. Finally, we observe behavioral differences in TGF-β mutants including in chemosensation and the establishment of the P. pacificus kin-recognition signal. Thus, TGF-β signaling in nematodes represents a stochastic genetic network capable of generating novel functions through the duplication and deletion of associated genes.
(© The Author(s) 2022. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.)