Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability.

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Abstrakt

Tytuł:: Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability.
Autorzy:: Bu C; Department of Medical Psychology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, People's Republic of China.
Hu S; Department of Medical Records, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, People's Republic of China.
Yu J; Department of Neurosurgery, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan, 450003, Zhengzhou, People's Republic of China.
Li N; Department of Neurosurgery, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan, 450003, Zhengzhou, People's Republic of China.
Gu J; Department of Neurosurgery, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan, 450003, Zhengzhou, People's Republic of China.
Sheng Z; Department of Neurosurgery, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan, 450003, Zhengzhou, People's Republic of China.
Yan Z; Department of Neurosurgery, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan, 450003, Zhengzhou, People's Republic of China.
Bu X; Department of Neurosurgery, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan, 450003, Zhengzhou, People's Republic of China. .
Źródło:: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2023 May; Vol. 25 (5), pp. 1378-1388. Date of Electronic Publication: 2022 Dec 09.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: <2010- >: Milan : Springer Italia
Original Publication: Barcelona, Spain : Doyma, c2005-
MeSH Terms:: Fear*/physiology
Fear*/psychology
Ferroptosis*/genetics
Ferroptosis*/physiology
Glioma*/genetics
Glioma*/psychology
Stress, Psychological*/etiology
Stress, Psychological*/genetics
Stress, Psychological*/psychology
Animals ; Humans ; Mice ; Cell Line, Tumor ; Depression/etiology ; Depression/genetics ; Depression/psychology ; Disease Models, Animal ; Gene Expression ; Methyltransferases/genetics ; Mice, Nude ; RNA, Messenger ; Up-Regulation/genetics
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Grant Information:: No.2019004 Education Development Foundation of Henan University; No. 192102310126 Key Scientific and Technological Projects in Henan Province
Contributed Indexing:: Keywords: FSP1and METTL3; Fear stress; Ferroptosis; Glioma; m6A
Substance Nomenclature:: 0 (ferroptosis suppressor protein 1, human)
EC 2.1.1.- (Methyltransferases)
EC 2.1.1.62 (METTL3 protein, human)
0 (RNA, Messenger)
Entry Date(s):: Date Created: 20221209 Date Completed: 20230426 Latest Revision: 20231213
Update Code:: 20240104
DOI:: 10.1007/s12094-022-03032-1
PMID:: 36484954
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Purpose: Patients diagnosed with cancer often suffer from emotional stressors, such as anxiety, depression, and fear of death. However, whether fear stress could influence the glioma progression is still unclear.
Methods: Xenograft glioma animal models were established in nude mice. Tumor-bearing mice were subjected to fear stress by living closely with cats and then their depressive behaviors were measured using an open field test. Hematoxylin and eosin staining, the TUNEL staining and immunochemical staining were used to detect the histopathological changes of tumor tissues. Gene expression profiling was used to screen the aberrant gene expression. Methylated RNA immunoprecipitation was used to identify the RNA m 6 A level. Gene expression was measured by western blot and real-time PCR, respectively.
Results: We found that fear stress promoted glioma tumor progression in mice. Fear stress-induced upregulation of METTL3 and FSP1, increased m 6 A level of glioma tumor tissues, and inhibited ferroptosis in glioma progression, which were reversed by knockdown of METTL3 and FSP1 in vivo. In addition, we found that when iFSP1 (a ferroptosis inducer by targeting inhibition of FSP1) was introduced to glioma cells, the cells viability of glioma significantly was decreased and ferroptosis was enhanced in glioma cells.
Conclusions: Fear stress-induced upregulation of METTL3 stabilized FSP1 mRNA by m 6 A modification, leading to tumor progression through inhibition of ferroptosis. Our study provides a new understanding of psychological effects on glioma development, and new insights for glioma therapy.
(© 2022. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).)

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