Predictors of seizure outcomes in patients with diffuse low-grade glioma-related epilepsy after complete glioma removal.

Tytuł:: Predictors of seizure outcomes in patients with diffuse low-grade glioma-related epilepsy after complete glioma removal.
Autorzy:: He X; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Zhang K; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Liu D; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Yang Z; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Li X; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Yang Z; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Źródło:: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2023 Feb; Vol. 29 (2), pp. 736-743. Date of Electronic Publication: 2022 Dec 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Oxford, UK : Wiley-Blackwell, c2008-
MeSH Terms:: Brain Neoplasms*/complications
Brain Neoplasms*/surgery
Brain Neoplasms*/pathology
Glioma*/complications
Glioma*/surgery
Glioma*/pathology
Epilepsy*/etiology
Epilepsy*/surgery
Epilepsy*/pathology
Humans ; Retrospective Studies ; Treatment Outcome ; Seizures/epidemiology ; Seizures/etiology ; Seizures/surgery
References:: N Engl J Med. 2016 Apr 7;374(14):1344-55. (PMID: 27050206)
Lancet Neurol. 2007 May;6(5):421-30. (PMID: 17434097)
Neurosurg Rev. 2009 Jul;32(3):275-84; discussion 284-6. (PMID: 19205766)
Ann Neurol. 2003 Oct;54(4):514-20. (PMID: 14520665)
Semin Oncol. 2003 Dec;30(6 Suppl 19):49-52. (PMID: 14765386)
Seizure. 2017 Oct;51:157-162. (PMID: 28873363)
J Neurosurg. 2018 Apr;128(4):1084-1090. (PMID: 28548599)
Ann Clin Transl Neurol. 2021 Jul;8(7):1446-1455. (PMID: 34057825)
Brain. 2012 Apr;135(Pt 4):1002-16. (PMID: 22171351)
CNS Neurosci Ther. 2023 Feb;29(2):736-743. (PMID: 36514187)
World Neurosurg. 2017 Oct;106:750-756. (PMID: 28673890)
Neuro Oncol. 2012 Sep;14 Suppl 4:iv55-64. (PMID: 23095831)
Sci Rep. 2021 Apr 19;11(1):8522. (PMID: 33875775)
Epilepsia. 2001 Feb;42(2):282-6. (PMID: 11240604)
J Neurol. 1999 Oct;246(10):926-33. (PMID: 10552240)
J Neurosurg. 2008 Feb;108(2):227-35. (PMID: 18240916)
J Oncol Pract. 2016 Dec;12(12):1235-1241. (PMID: 27943684)
Acta Neurochir (Wien). 2000;142(1):1-15. (PMID: 10664370)
Neuro Oncol. 2018 Feb 19;20(3):324-331. (PMID: 29016869)
J Neurosurg. 2019 Oct 4;:1-8. (PMID: 31585428)
Neurosurgery. 2019 Aug 1;85(2):E332-E340. (PMID: 30395304)
Brain. 2014 Feb;137(Pt 2):449-62. (PMID: 24374407)
Cancer Med. 2019 Aug;8(10):4527-4535. (PMID: 31240876)
Ann Neurol. 1993 Dec;34(6):774-80. (PMID: 8250525)
Childs Nerv Syst. 2016 Oct;32(10):1839-48. (PMID: 27659827)
Epilepsia. 2013 Dec;54 Suppl 9:30-4. (PMID: 24328869)
Cancers (Basel). 2020 Feb 08;12(2):. (PMID: 32046310)
Neuro Oncol. 2012 Feb;14(2):230-41. (PMID: 22187341)
J Neurosurg. 2011 Aug;115(2):240-4. (PMID: 21529134)
Curr Neurol Neurosci Rep. 2016 Nov;16(11):97. (PMID: 27662895)
Acta Neuropathol. 1996;91(4):376-84. (PMID: 8928614)
Acta Neuropathol. 2016 Jun;131(6):803-20. (PMID: 27157931)
Contributed Indexing:: Keywords: diffuse low-grade glioma; diffuse low-grade glioma-related epilepsy; epilepsy; seizure outcomes
Entry Date(s):: Date Created: 20221213 Date Completed: 20230126 Latest Revision: 20230222
Update Code:: 20240105
PubMed Central ID:: PMC9873512
DOI:: 10.1111/cns.14061
PMID:: 36514187
: Czasopismo naukowe

Pełny tekst

Aims: We aimed to identify predictors of postoperative seizures in patients with diffuse low-grade glioma (DLGG)-related epilepsy after complete tumor resection in this study.
Methods: We retrospectively collected data from individuals with DLGG-related epilepsy whose tumors were completely resected at Xiangya Hospital, Central South University between January 2014 and January 2020. The predictors of seizure outcomes were assessed by employing univariate analysis and a multivariate logistic regression model in a backward binary logistic regression model.
Results: Among the 118 cases that met the inclusion criteria, 83.05% were seizure-free following an average follow-up of 4.27 ± 1.65 years, all of whom were classified as International League Against Epilepsy class I outcome. Univariate and multivariate analyses indicated that seizure duration of >6 years (odds ratio [OR], 6.62; 95% confidence interval [CI], 1.76-24.98; p = 0.005) and first clinical symptoms other than seizures (OR, 4.51; 95% CI, 1.43-14.23; p = 1.010) were both independent predictors of unfavorable seizure outcomes.
Conclusion: Our results imply that satisfactory seizure outcomes can be achieved in most patients with DLGG-related epilepsy after complete tumor resection. Patients with seizure duration of >6 years or first clinical symptoms other than seizures were more likely to experience postoperative seizure recurrence.
(© 2022 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)

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