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Tytuł:
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On the structural origin of the anisotropy in the myocardium: Multiscale modeling and analysis.
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Autorzy:
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Tueni N; LMS, CNRS/École Polytechnique/Institut Polytechnique de Paris, Palaiseau, France; Inria, Palaiseau, France.
Allain JM; LMS, CNRS/École Polytechnique/Institut Polytechnique de Paris, Palaiseau, France; Inria, Palaiseau, France.
Genet M; LMS, CNRS/École Polytechnique/Institut Polytechnique de Paris, Palaiseau, France; Inria, Palaiseau, France. Electronic address: .
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Źródło:
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Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2023 Feb; Vol. 138, pp. 105600. Date of Electronic Publication: 2022 Dec 12.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam : Elsevier
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MeSH Terms:
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Myocardium*
Collagen*/chemistry
Anisotropy ; Muscle, Skeletal ; Stress, Mechanical
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Contributed Indexing:
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Keywords: Micromechanical modeling; Myocardium; Optimization; Orthotropy; Periodic homogenization; Structure–properties relationship
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Substance Nomenclature:
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9007-34-5 (Collagen)
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Entry Date(s):
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Date Created: 20221216 Date Completed: 20230118 Latest Revision: 20230223
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Update Code:
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20240105
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DOI:
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10.1016/j.jmbbm.2022.105600
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PMID:
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36525875
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Due to structural heterogeneities within the tissue, the myocardium displays an orthotropic material behavior. However, the link between the microstructure and the macroscopic mechanical properties is still not fully established. In particular, if it is admitted that the cardiomyocyte organization induces a transversely isotropic symmetry, the relative role in the observed orthotropic symmetry of cardiomyocyte orientation variation and perimysium collagen "sheetlet" structure, two mechanisms occurring at different scales, is still a matter of debate. In order to shed light on this question, we designed a multiscale model of the myocardium, bridging the cell, sheetlet and tissue scales. More precisely, we compared the macroscopic anisotropy obtained by homogenization of different mesostructures consisting in cardiomyocytes and extracellular collageneous layers, also taking into account the variation of cardiomyocyte and sheetlet orientations on the macroscale, to available experimental data. This study confirms the importance of sheetlets layers in assuring the tissue's anisotropic response, as cardiomyocytes-only mesostructures cannot reproduce the observed anisotropy. Moreover, our model shows the existence of a size effect in the myocardial tissue shear properties, which will require further experimental analysis.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)