Genotoxicity and Reproductive Risk in Workers Exposed to Pesticides in Rural Areas of Curicó, Chile: A Pilot Study.

Szczegóły
Abstrakt

Tytuł:: Genotoxicity and Reproductive Risk in Workers Exposed to Pesticides in Rural Areas of Curicó, Chile: A Pilot Study.
Autorzy:: Landeros N; Centro Oncológico, Facultad de Medicina, Universidad de Católica del Maule, Talca 3466706, Chile.; Laboratorio de Investigaciones Biomédicas (LIB), Facultad de Medicina, Universidad de Católica del Maule, Talca 3466706, Chile.
Duk S; Laboratorio de Citogenética y Genética Toxicológica, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070386, Chile.
Márquez C; Laboratorio de Citogenética y Genética Toxicológica, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070386, Chile.
Inzunza B; Laboratorio de Citogenética y Genética Toxicológica, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070386, Chile.
Acuña-Rodríguez IS; Instituto de Investigaciones Interdisciplinarias (I3), Universidad de Talca, Talca 3465548, Chile.
Zúñiga-Venegas LA; Laboratorio de Investigaciones Biomédicas (LIB), Facultad de Medicina, Universidad de Católica del Maule, Talca 3466706, Chile.; Centro de Investigación de Estudios Avanzados del Maule (CIEAM), Universidad Católica del Maule, Talca 3466706, Chile.
Źródło:: International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Dec 10; Vol. 19 (24). Date of Electronic Publication: 2022 Dec 10.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel : MDPI, c2004-
MeSH Terms:: Pesticides*/toxicity
Pesticides*/analysis
Occupational Exposure*/adverse effects
Occupational Exposure*/analysis
Humans ; Female ; Pilot Projects ; Chile/epidemiology ; DNA Damage
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Contributed Indexing:: Keywords: Chile; agricultural workers; genotoxicity; pesticide exposure; reproductive risk
Substance Nomenclature:: 0 (Pesticides)
Entry Date(s):: Date Created: 20221223 Date Completed: 20221226 Latest Revision: 20230123
Update Code:: 20230123
PubMed Central ID:: PMC9779056
DOI:: 10.3390/ijerph192416608
PMID:: 36554491
: Czasopismo naukowe

Significant risks to human health have been associated with chronic exposure to low doses of pesticides, a situation which may be frequent among agricultural workers. In this context, and regarding the agricultural-based economy of central Chile, we aimed to explore the genotoxic damage in agricultural workers and reproductive risk among women in rural and urban areas of Curicó, a traditional agricultural district in Chile. Hence, we sampled a group of rural agricultural workers associated with pesticide management ( n = 30) and an urban unexposed group ( n = 30). Our results showed that the agricultural workers had higher micronuclei frequencies (MN: β = 13.27; 95% CI low = 11.08, CI high = 15.47) and women had a 40-fold higher risk of reproductive problems (OR = 40.32; 95% CI low = 2.60, CI high = 624.31) than the unexposed group. The factor analysis of mixed data (FAMD) showed that neither the sex nor smoking habits appear to define the ordination of the data. Nevertheless, the exposure level did segregate them in the multidimensional space (explained variance: 35.38% dim-1; 18.63% dim-2). This pilot study highlights the higher risks of biological conditions negatively associated with the health of agricultural workers.

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