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Tytuł:
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Highly Dispersed Cu Produced by Mechanical Stress-Activated Redox Reaction to Establish Galvanic Corrosion in Fe Implant.
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Autorzy:
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He C; State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha410083, China.
Zeng X; Department of Gynecology, The Third Xiangya Hospital, Central South University, Changsha410013, China, China.
Yang L; Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou341119, China.
Zhong S; Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang330013, China.
Peng S; The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha410078, China.; NHC Key Laboratory of Carcinogenesis of Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha410013, China.; School of energy and machinery engineering, Jiangxi University of Science and Technology, Nanchang330013, China.
Yang W; Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang330013, China.
Shuai C; State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha410083, China.; Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang330013, China.
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Źródło:
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ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2023 Jan 09; Vol. 9 (1), pp. 153-164. Date of Electronic Publication: 2022 Dec 26.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Washington, DC : American Chemical Society, [2015]-
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MeSH Terms:
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Prostheses and Implants*
Stress, Mechanical ; Corrosion ; Oxidation-Reduction
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Contributed Indexing:
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Keywords: Fe−Cu implant; galvanic corrosion; redox reaction; shift-speed ball milling
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Substance Nomenclature:
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V1XJQ704R4 (cupric oxide)
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Entry Date(s):
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Date Created: 20221226 Date Completed: 20230110 Latest Revision: 20230210
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Update Code:
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20240105
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DOI:
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10.1021/acsbiomaterials.2c00831
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PMID:
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36571764
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Fe has immense potential for biodegradable orthopedic applications, but it degrades slowly in the physiological environment. Inducing galvanic couple by alloying Cu to Fe using ball milling is a promising approach. However, the ductile nature of Cu leads to the cold welding of a large amount of Cu powder during ball milling, which makes it difficult to disperse uniformly in the Fe matrix. Here, a Fe-CuO implant with highly dispersed Cu particles in the matrix was developed by shift-speed ball milling and selective laser melting. Specifically, copper oxide (CuO) particles were selected as precursors and dispersed in Fe powders by ball milling since they were brittle and would not be cold-welded during ball milling. After further milling in higher energy, it was found that CuO particles reacted with Fe and generated Cu particles through a stress-activated redox reaction. Subsequently, the obtained powders were prepared into a Fe-CuO implant using selective laser melting. Microstructure examination revealed that the Cu phases in the implant were dispersed evenly in the Fe matrix, which was considered to establish a large number of galvanic couples and aggravated the galvanic corrosion tendency. Electrochemical tests indicated that the implant had improved performance in degradation behavior in terms of high corrosion current density (22.4 μA/cm 2 ), low corrosion resistance (1319 Ω cm 2 ), and good degradation stability. In addition, it presented antibacterial effects against Escherichia coli and Staphylococcus aureus by diffusion mechanisms with killing rates of 90.7 and 96.7%, respectively, as well as good cytocompatibility.
