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Tytuł:
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Astaxanthin attenuates cigarette smoking-induced oxidative stress and inflammation in a sirtuin 1-dependent manner.
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Autorzy:
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Deng M; National Center for Respiratory Medicine; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital. No.2, East Yinghua Road, Chaoyang District, Beijing 100029, China.
Tong R; National Center for Respiratory Medicine; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital. No.2, East Yinghua Road, Chaoyang District, Beijing 100029, China.
Bian Y; National Center for Respiratory Medicine; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital. No.2, East Yinghua Road, Chaoyang District, Beijing 100029, China.
Hou G; National Center for Respiratory Medicine; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital. No.2, East Yinghua Road, Chaoyang District, Beijing 100029, China.. Electronic address: .
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Źródło:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Mar; Vol. 159, pp. 114230. Date of Electronic Publication: 2023 Jan 23.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Paris : Editions Scientifiques Elsevier
Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
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MeSH Terms:
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Cigarette Smoking*
Pulmonary Disease, Chronic Obstructive*/drug therapy
Pulmonary Disease, Chronic Obstructive*/metabolism
Mice ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Sirtuin 1/metabolism ; NF-kappa B/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Inflammation/metabolism ; Nicotiana ; Disease Models, Animal
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Contributed Indexing:
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Keywords: Astaxanthin; Chronic inflammation; Chronic obstructive pulmonary disease; Oxidative stress; SIRT1
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Substance Nomenclature:
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0 (Antioxidants)
EC 3.5.1.- (Sirtuin 1)
0 (NF-kappa B)
8XPW32PR7I (astaxanthine)
0 (NF-E2-Related Factor 2)
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Entry Date(s):
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Date Created: 20230125 Date Completed: 20230207 Latest Revision: 20231213
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Update Code:
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20240105
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DOI:
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10.1016/j.biopha.2023.114230
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PMID:
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36696799
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Oxidative stress and chronic inflammation play key roles in the pathogenesis of chronic obstructive pulmonary disease (COPD). Astaxanthin (AXT) is a keto-carotenoid with a variety of biological functions, including antioxidant and anti-inflammatory effects This study aimed to explore the protective role and underlying mechanism of AXT in the pathogenesis of COPD. In this study, we found AXT alleviated pulmonary emphysema in a CS-exposed mouse model and regulated the expression of MMP-9/TIMP-1. And, AXT attenuates CSE-induced small airway fibrosis. Meanwhile, AXT inhibited Nrf2-modulated oxidative stress and the p65 NF-κB-regulated inflammatory pathway in both the mouse model and CSE-treated HBE cells. Mechanistically, AXT could directly bind to SIRT1 (the binding energy of the complex was -8.8 kcal/mol) and regulate the deacetylation activity of SIRT1. Finally, by activating SIRT1 deacetylation, AXT deacetylated Nrf2 and contributed to its action of reducing oxidative stress by generating antioxidant enzymes, and inhibiting p65 NF-κB transcriptional activity to suppress the inflammatory response. Our results show that treatment with AXT significantly reverses the oxidative stress and inflammation induced by cigarette smoke both in vivo and in vitro in a sirtuin 1-dependent manner.
Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests.
(Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
