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Tytuł:
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Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: A Randomized controlled trial.
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Autorzy:
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Lago J; Immunology Service, Professor Edgard Santos University Hospital Complex, Federal University of Bahia, Salvador, Bahia, Brazil.; Post-Graduate Course in Health Sciences, Federal University of Bahia Medical School. Salvador, Bahia, Brazil.
Fraga D; Gonçalo Moniz Institute (IGM), Fiocruz, Salvador, Bahia, Brazil.
Guimarães LH; Federal University of Southern Bahia, Teixeira de Freitas, Bahia, Brazil.
Lago T; Immunology Service, Professor Edgard Santos University Hospital Complex, Federal University of Bahia, Salvador, Bahia, Brazil.; Post-Graduate Course in Health Sciences, Federal University of Bahia Medical School. Salvador, Bahia, Brazil.
Silva YJ; Gonçalo Moniz Institute (IGM), Fiocruz, Salvador, Bahia, Brazil.
Lago E; Immunology Service, Professor Edgard Santos University Hospital Complex, Federal University of Bahia, Salvador, Bahia, Brazil.; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Ministério da Ciência e Tecnologia e Inovação (MCTI), CNPq, Salvador, Bahia, Brazil.
Werneck GL; Department of Epidemiology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.; Institute for Public Health Studies, Federal University of Rio de Janeiro. Federal.
Bacellar O; Immunology Service, Professor Edgard Santos University Hospital Complex, Federal University of Bahia, Salvador, Bahia, Brazil.; Post-Graduate Course in Health Sciences, Federal University of Bahia Medical School. Salvador, Bahia, Brazil.; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Ministério da Ciência e Tecnologia e Inovação (MCTI), CNPq, Salvador, Bahia, Brazil.
Carvalho EM; Immunology Service, Professor Edgard Santos University Hospital Complex, Federal University of Bahia, Salvador, Bahia, Brazil.; Post-Graduate Course in Health Sciences, Federal University of Bahia Medical School. Salvador, Bahia, Brazil.; Gonçalo Moniz Institute (IGM), Fiocruz, Salvador, Bahia, Brazil.; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Ministério da Ciência e Tecnologia e Inovação (MCTI), CNPq, Salvador, Bahia, Brazil.
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Źródło:
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PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Feb 15; Vol. 17 (2), pp. e0011064. Date of Electronic Publication: 2023 Feb 15 (Print Publication: 2023).
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Typ publikacji:
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Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: San Francisco, CA : Public Library of Science
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MeSH Terms:
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Antiprotozoal Agents*/therapeutic use
Leishmaniasis, Cutaneous*/pathology
Organometallic Compounds*/therapeutic use
Leishmania braziliensis*
Humans ; Dogs ; Animals ; Meglumine Antimoniate/therapeutic use ; Meglumine/therapeutic use ; Saline Solution/therapeutic use ; Ulcer/drug therapy
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References:
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Molecular Sequence:
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figshare 10.6084/m9.figshare.21788174
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Substance Nomenclature:
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75G4TW236W (Meglumine Antimoniate)
0 (Antiprotozoal Agents)
6HG8UB2MUY (Meglumine)
0 (Saline Solution)
0 (Organometallic Compounds)
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Entry Date(s):
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Date Created: 20230215 Date Completed: 20230217 Latest Revision: 20230407
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Update Code:
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20240105
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PubMed Central ID:
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PMC9931096
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DOI:
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10.1371/journal.pntd.0011064
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PMID:
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36791065
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Dogs living in areas of Leishmania (Viannia) braziliensis transmission may present canine tegumentary leishmaniasis (CTL) characterized by cutaneous or muzzle ulcers as well as asymptomatic L. braziliensis infection. It is not clear if dogs participate in the transmission chain of L. braziliensis to humans. However, dogs may remain with chronic ulcers for a long time, and as there are no public policies about CTL, these animals die or are sacrificed. Here we compare the efficacy of intralesional meglumine antimoniate with intralesional 0.9% NaCl solution in CTL treatment. This randomized control study included 32 dogs with cutaneous or muzzle lesions who had L. braziliensis DNA detected by PCR in tissue biopsied. Group one received 5ml of intralesional Glucantime, and group two received 5ml 0.9% NaCl solution, both applied in the four cardinal points on days 0, 15, and 30. Cure was defined as complete healing of the ulcers in the absence of raised borders on day 90. There was no difference in animals' demographic and clinical features in the two groups (p >.05). While at the endpoint, the cure rate was 87.5% in the group test, and in those who received 0.9 NaCl the cure rate was only 12.5%. As important as the high cure rate, the healing time was faster in dogs treated with antimony than in those treated with saline (p < .001). Intralesional meglumine antimoniate is effective in the treatment of dogs with L. braziliensis infection and accelerates the healing time of CTL.
Competing Interests: We declare that there is no relationship or support which might be perceived as constituting a conflict of interest.
(Copyright: © 2023 Lago et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Erratum in: PLoS Negl Trop Dis. 2023 Apr 5;17(4):e0011261. (PMID: 37018217)
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