Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation.

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Tytuł:: Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation.
Autorzy:: Kawaue T; Mechanobiology Institute, National University of Singapore, Singapore; Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan.
Yow I; Mechanobiology Institute, National University of Singapore, Singapore.
Pan Y; Mechanobiology Institute, National University of Singapore, Singapore.
Le AP; Mechanobiology Institute, National University of Singapore, Singapore.
Lou Y; Mechanobiology Institute, National University of Singapore, Singapore.
Loberas M; Mechanobiology Institute, National University of Singapore, Singapore.
Shagirov M; Mechanobiology Institute, National University of Singapore, Singapore.
Teng X; Mechanobiology Institute, National University of Singapore, Singapore.
Prost J; Physico Chimie Curie, Institut Curie, CNRS, UMR 168, 75005 Paris, France.
Hiraiwa T; Mechanobiology Institute, National University of Singapore, Singapore.
Ladoux B; Université Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, France.
Toyama Y; Mechanobiology Institute, National University of Singapore, Singapore; Department of Biological Sciences, National University of Singapore, Singapore. Electronic address: .
Źródło:: Developmental cell [Dev Cell] 2023 Feb 27; Vol. 58 (4), pp. 267-277.e5. Date of Electronic Publication: 2023 Feb 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Cambridge, Mass. : Cell Press, c2001-
MeSH Terms:: Mechanotransduction, Cellular*
Apoptosis*/physiology
Animals ; Dogs ; Cell Death ; Cell Division ; Madin Darby Canine Kidney Cells ; Cell Proliferation/physiology
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Grant Information:: 101019835 International ERC_ European Research Council
Contributed Indexing:: Keywords: YAP; apoptosis; cell division; compensatory proliferation; mechanotransduction; tissue homeostasis
Entry Date(s):: Date Created: 20230221 Date Completed: 20230302 Latest Revision: 20230701
Update Code:: 20240105
PubMed Central ID:: PMC7614677
DOI:: 10.1016/j.devcel.2023.01.005
PMID:: 36800994
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The number of cells in tissues is controlled by cell division and cell death, and its misregulation could lead to pathological conditions such as cancer. To maintain the cell numbers, a cell-elimination process called apoptosis also stimulates the proliferation of neighboring cells. This mechanism, apoptosis-induced compensatory proliferation, was originally described more than 40 years ago. Although only a limited number of the neighboring cells need to divide to compensate for the apoptotic cell loss, the mechanisms that select cells to divide have remained elusive. Here, we found that spatial inhomogeneity in Yes-associated protein (YAP)-mediated mechanotransduction in neighboring tissues determines the inhomogeneity of compensatory proliferation in Madin-Darby canine kidney (MDCK) cells. Such inhomogeneity arises from the non-uniform distribution of nuclear size and the non-uniform pattern of mechanical force applied to neighboring cells. Our findings from a mechanical perspective provide additional insight into how tissues precisely maintain homeostasis.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2023 Elsevier Inc. All rights reserved.)

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