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Tytuł pozycji:

Mass transport limitations for electrochemical sensing in low-flux excretory fluids.

Tytuł:
Mass transport limitations for electrochemical sensing in low-flux excretory fluids.
Autorzy:
Komkova MA; Chemistry Faculty of M.V. Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow, 119991, Russia.
Poyarkov AA; Materials Science Faculty of M.V. Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow, 119991, Russia.
Eliseev AA; Chemistry Faculty of M.V. Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow, 119991, Russia.
Eliseev AA; Chemistry Faculty of M.V. Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow, 119991, Russia; Materials Science Faculty of M.V. Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow, 119991, Russia. Electronic address: .
Źródło:
Biosensors & bioelectronics [Biosens Bioelectron] 2023 May 01; Vol. 227, pp. 115148. Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: Oxford : Elsevier Advanced Technology
Original Publication: [Barking, Essex, England] : Elsevier Applied Science, 1989-
MeSH Terms:
Biosensing Techniques*
Wearable Electronic Devices*
Body Fluids*/chemistry
Reproducibility of Results ; Glucose/analysis ; Sweat/chemistry
Contributed Indexing:
Keywords: Amperometry; Continuous sweat analysis; Low flux; Non-invasive diagnostics; Wearable biosensors
Substance Nomenclature:
IY9XDZ35W2 (Glucose)
Entry Date(s):
Date Created: 20230225 Date Completed: 20230314 Latest Revision: 20230314
Update Code:
20240105
DOI:
10.1016/j.bios.2023.115148
PMID:
36841113
Czasopismo naukowe
Despite non-invasive instant monitoring of sweat metabolites is becoming a general trend in early diagnostics and screening, the reliability and accuracy of the on-skin electrochemical biosensors in real-life scenarios still remain questionable. As a rule, mass transport effects in scantily excreted liquids are ignored, when considering the design of such wearable setups. Here we provide a comprehensive investigation of the disruption factors for commonly used Prussian Blue based (bio)sensors under different hydrodynamic conditions (2 × 10 -5 - 5 × 10 0  mm s -1 electrolyte velocity). A huge effect of flow on the (bio)sensors response has been revealed and explained with transport limitations for both analyte influx and reaction product outflux. It suggests no need for improving the sensor sensitivity, while minimizing analyte consumption and enhancing product withdrawal. Some strategies concerning measurement schemes and sensor design ensuring reliable sweat analysis have been discussed and illustrated for lactate and glucose on-skin monitoring.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)

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