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Tytuł:
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Pteris laeta Wall. and Its New Phytochemical, Pterosinsade A, Promote Hippocampal Neurogenesis via Activating the Wnt Signaling Pathway.
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Autorzy:
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Shi YS; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; Academy of Integrative Medicine, Dalian Medical University, Dalian 116044, China.
Chen JC; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Lin BH; The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510920, China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Wang RN; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; College of Basic Medical Sciences, Dalian Medical University, Dalian 116600, China.
Zhao J; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; College of Basic Medical Sciences, Dalian Medical University, Dalian 116600, China.
Li S; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; College of Basic Medical Sciences, Dalian Medical University, Dalian 116600, China.
Zhang Y; The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510920, China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.; Chiba University, Matsudo 2718501, Japan.
Zhang XF; The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510920, China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
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Źródło:
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Journal of agricultural and food chemistry [J Agric Food Chem] 2023 Mar 22; Vol. 71 (11), pp. 4586-4598. Date of Electronic Publication: 2023 Mar 09.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Washington, American Chemical Society.
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MeSH Terms:
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Pteris*/metabolism
Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Mice ; Animals ; Wnt Signaling Pathway ; Mice, Transgenic ; Disease Models, Animal ; Neurogenesis ; Hippocampus ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism
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Contributed Indexing:
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Keywords: Alzheimer’s disease; Pteris laeta Wall.; Wnt signaling pathway; hippocampal neurogenesis; neural stem cell; pterosinsade A
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Substance Nomenclature:
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0 (Amyloid beta-Peptides)
0 (Amyloid beta-Protein Precursor)
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Entry Date(s):
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Date Created: 20230309 Date Completed: 20230323 Latest Revision: 20240322
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Update Code:
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20240323
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DOI:
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10.1021/acs.jafc.2c08493
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PMID:
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36892329
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Pteris laeta Wall., as a traditional tea, is popular in Southwest China, but its role in preventing cognitive impairment is unclear. In this study, Pteris laeta Wall. extracts (PW) and its active compounds were evaluated for preventive effects on Alzheimer's disease (AD) in vivo and in vitro . The results showed that PW diminished oxidative stress damage and apoptosis of Aβ-induced HT22 cells and also rescued cognitive deficits, and ameliorated pathological injury and inflammatory response in APP/PS1 mice. Besides, a new pterosin sesquiterpene, named pterosinsade A (PA), and nine known compounds were discovered from the EtOAc extract that possessed the best neuroprotective activity. PA reduced apoptosis of APP-overexpressing neural stem cells and promoted their proliferation and neuronal differentiation. Meanwhile, PW and PA promoted hippocampal neurogenesis, which proved to be associated with activating the Wnt signaling pathway. These findings suggest that PW and PA are candidates for AD prevention.
Erratum in: J Agric Food Chem. 2024 Mar 22;:. (PMID: 38518122)
