CLIPPERS Syndrome After Vaccination. An Unusual ASIA Presentation.

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Abstrakt

Tytuł:: CLIPPERS Syndrome After Vaccination. An Unusual ASIA Presentation.
Autorzy:: Saénz-Silva J; Department of Neurology, Hospital de Especialidades «Dr. Antonio Fraga Mouret»,Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Ordinola Navarro A; Department of Internal medicine, Hospital de Especialidades «Dr. Antonio Fraga Mouret», Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico. Electronic address: .
Źródło:: Reumatologia clinica [Reumatol Clin (Engl Ed)] 2023 Mar; Vol. 19 (3), pp. 168-170.
Typ publikacji:: Case Reports
Język:: English
Imprint Name(s):: Original Publication: [Barcelona?] : Elsevier Doyma
MeSH Terms:: Adrenal Cortex Hormones*/adverse effects
Adrenal Cortex Hormones*/therapeutic use
Inflammation*/diagnosis
Inflammation*/drug therapy
Inflammation*/pathology
Vaccination*/adverse effects
Chronic Disease*
Adult ; Humans ; Magnetic Resonance Imaging ; Steroids/adverse effects ; Syndrome
Contributed Indexing:: Keywords: ASIA; CLIPPERS; Eventos relacionados a vacunación; Influenza; Manifestaciones neurológicas; Neurology manifestations; Vaccine-related event
Substance Nomenclature:: 0 (Adrenal Cortex Hormones)
0 (Steroids)
Entry Date(s):: Date Created: 20230311 Date Completed: 20230517 Latest Revision: 20230517
Update Code:: 20240104
DOI:: 10.1016/j.reumae.2021.10.003
PMID:: 36906391
: Raport

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The chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) and autoimmune/inflammatory syndrome induced by adjuvants (ASIA) were described a decade ago. There are a limited number of reports and these diseases are still underdiagnosed. We presented a 35 years-old patient with clinical manifestations of cerebellum affection and enhancement in the MRI, with the influenza vaccine as the only triggering factor. Infectious diseases, malignancy, and additional systemic involvement were ruled out; therefore, on suspicion of CLIPPERS syndrome, the patient received corticosteroid therapy with an adequate response. The knowledge of CLIPPERS syndrome as an unusual ASIA presentation and high response to the corticosteroids may lead to a timely diagnosis, appropriate treatment, and follow up with better outcomes for patients.
(Copyright © 2021 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)

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