Response to Bovine Viral Diarrhea Virus in Heifers Vaccinated with a Combination of Multivalent Modified Live and Inactivated Viral Vaccines.

Tytuł:: Response to Bovine Viral Diarrhea Virus in Heifers Vaccinated with a Combination of Multivalent Modified Live and Inactivated Viral Vaccines.
Autorzy:: Falkenberg SM; Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA.; Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Dassanayake RP; Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA.
Crawford L; Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA.
Sarlo Davila K; Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA.
Boggiatto P; Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA.
Źródło:: Viruses [Viruses] 2023 Mar 08; Vol. 15 (3). Date of Electronic Publication: 2023 Mar 08.
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI
MeSH Terms:: Bovine Virus Diarrhea-Mucosal Disease*
Diarrhea Viruses, Bovine Viral*
Viral Vaccines*
Female ; Animals ; Cattle ; Vaccines, Inactivated ; Antibodies, Viral ; Diarrhea
References:: Vet Immunol Immunopathol. 2020 Mar;221:110024. (PMID: 32070831)
J Vet Med B Infect Dis Vet Public Health. 2002 Dec;49(10):489-93. (PMID: 12485359)
Pathogens. 2018 Mar 08;7(1):. (PMID: 29518049)
Vet Immunol Immunopathol. 2017 May;187:20-27. (PMID: 28494925)
Vet Microbiol. 2000 Nov 15;77(1-2):145-55. (PMID: 11042408)
Vet Ther. 2009 Winter;10(4):E1-8. (PMID: 20425730)
Res Vet Sci. 2020 Apr;129:109-116. (PMID: 31954315)
Vet Ther. 2000 Winter;1(1):49-58. (PMID: 19757565)
Am J Vet Res. 1995 Jun;56(6):755-9. (PMID: 7653884)
Nat Microbiol. 2020 May;5(5):668-674. (PMID: 32341570)
Vaccine. 2020 Aug 10;38(36):5764-5772. (PMID: 32690424)
Vaccine. 2017 Feb 15;35(7):1046-1054. (PMID: 28111144)
Philos Trans R Soc Lond B Biol Sci. 1994 Nov 29;346(1317):323-31. (PMID: 7708827)
Vaccine. 2009 Jul 16;27(33):4508-19. (PMID: 19446589)
Vet Clin North Am Food Anim Pract. 2004 Mar;20(1):115-29. (PMID: 15062478)
J Vet Diagn Invest. 2014 Jan;26(1):10-7. (PMID: 24415196)
Vet Microbiol. 2017 Jul;206:69-77. (PMID: 28377131)
Vet Clin North Am Food Anim Pract. 2016 Jul;32(2):425-41. (PMID: 27140298)
Theriogenology. 2015 Feb;83(3):360-365.e1. (PMID: 25447148)
Prev Vet Med. 2005 Nov 15;72(1-2):109-14; discussion 215-9. (PMID: 16169620)
Am J Vet Res. 2006 Jul;67(7):1179-84. (PMID: 16817740)
J Infect Dis. 2021 Jun 15;223(12):2164-2173. (PMID: 33074330)
Front Vet Sci. 2021 Jun 15;8:685114. (PMID: 34212022)
J Vet Diagn Invest. 1991 Jul;3(3):199-203. (PMID: 1655059)
Am J Vet Res. 2018 Nov;79(11):1166-1178. (PMID: 30372148)
Vet Rec. 1995 Jul 15;137(3):58-62. (PMID: 8533232)
Integr Comp Biol. 2014 Sep;54(3):340-52. (PMID: 24944113)
Vet Immunol Immunopathol. 2008 Mar 15;122(1-2):8-15. (PMID: 18190971)
Integr Comp Biol. 2022 Dec 30;62(6):1629-1639. (PMID: 35561702)
Vaccine. 2018 Jun 18;36(26):3853-3860. (PMID: 29699786)
J Gen Virol. 1988 Jun;69 ( Pt 6):1399-403. (PMID: 2838577)
Contributed Indexing:: Keywords: bovine viral diarrhea virus; cell mediated response; viral vaccines; virus neutralizing titer
Substance Nomenclature:: 0 (Vaccines, Inactivated)
0 (Antibodies, Viral)
0 (Viral Vaccines)
Entry Date(s):: Date Created: 20230330 Date Completed: 20230331 Latest Revision: 20230414
Update Code:: 20240104
PubMed Central ID:: PMC10054639
DOI:: 10.3390/v15030703
PMID:: 36992412
: Czasopismo naukowe

Pełny tekst

Bovine viral vaccines contain both live or inactivated/killed formulations, but few studies have evaluated the impact of vaccinating with either live or killed antigens and re-vaccinating with the reciprocal. Commercial dairy heifers were utilized for the study and randomly assigned to three treatment groups. Treatment groups received a commercially available modified-live viral (MLV) vaccine containing BVDV and were revaccinated with a commercially available killed viral (KV) vaccine containing BVDV, another group received the same KV vaccine and was revaccinated with the same MLV vaccine, and yet another group served as negative controls and did not receive any viral vaccines. Heifers in KV/MLV had higher virus neutralizing titers (VNT) at the end of the vaccination period than heifers in MLV/KV and control groups. The frequency of IFN-γ mRNA positive CD4+, CD8+, and CD335+ populations, as well as increased mean fluorescent intensity of CD25+ cells was increased for the MLV/KV heifers as compared to KV/MLV and controls. The data from this study would suggest that differences in initial antigen presentation such as live versus killed could augment CMI and humoral responses and could be useful in determining vaccination programs for optimizing protective responses, which is critical for promoting lifetime immunity.

Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Informacja