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Tytuł:
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Hyaluronic acid-quercetin pendant drug conjugate for wound healing applications.
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Autorzy:
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Rao KM; School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea; Research Institute of cell culture, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address: .
Kim E; School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea.
Kim HJ; School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea.
Uthappa UT; School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea.
Han SS; School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea; Research Institute of cell culture, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address: .
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Źródło:
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International journal of biological macromolecules [Int J Biol Macromol] 2023 Jun 15; Vol. 240, pp. 124336. Date of Electronic Publication: 2023 Apr 06.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Guildford, Eng., IPC Science and Technology Press.
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MeSH Terms:
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Hyaluronic Acid*/chemistry
Quercetin*/pharmacology
Quercetin*/chemistry
Wound Healing ; Antioxidants/chemistry ; Water
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Contributed Indexing:
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Keywords: Hyaluronic acid; Pendant conjugate; Quercetin; Wound healing
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Substance Nomenclature:
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9004-61-9 (Hyaluronic Acid)
9IKM0I5T1E (Quercetin)
0 (Antioxidants)
059QF0KO0R (Water)
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Entry Date(s):
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Date Created: 20230408 Date Completed: 20230526 Latest Revision: 20230526
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Update Code:
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20240105
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DOI:
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10.1016/j.ijbiomac.2023.124336
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PMID:
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37030466
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In this study, a simple approach was used for the synthesis of a water-soluble hyaluronic acid-quercetin (HA-Q) pendant drug conjugate to evaluate its potential wound-healing properties. The HA-Q conjugation was confirmed by Fourier-transform infrared spectroscopy (FTIR), ultraviolet-visible spectrophotometry (UV-Vis), and nuclear magnetic resonance (NMR) spectroscopy techniques. To produce the HA-Q, quercetin was conjugated on the HA backbone to the extent of 44.7 %. The HA-Q conjugate was soluble in water and a solution with a concentration of 20 mg/ml was prepared. The conjugate exhibited good biocompatibility and supported the growth and cell migration of skin fibroblast cells. HA-Q presented improved radical scavenging capacity compared to quercetin (Q) alone. The overall results confirmed the potential role of HA-Q in wound healing applications.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
