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Tytuł:
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Bta-miR-206 and a Novel lncRNA-lncA2B1 Promote Myogenesis of Skeletal Muscle Satellite Cells via Common Binding Protein HNRNPA2B1.
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Autorzy:
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Zhang J; Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, Tianjin 300384, China.; College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China.
Sheng H; Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, Tianjin 300384, China.; College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China.
Zhang L; Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, Tianjin 300384, China.; College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China.
Li X; Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, Tianjin 300384, China.; College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China.
Guo Y; Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, Tianjin 300384, China.; College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China.
Wang Y; Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, Tianjin 300384, China.; College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China.
Guo H; Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, Tianjin 300384, China.; College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China.
Ding X; Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, Tianjin 300384, China.; College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China.
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Źródło:
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Cells [Cells] 2023 Mar 27; Vol. 12 (7). Date of Electronic Publication: 2023 Mar 27.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Basel, Switzerland : MDPI
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MeSH Terms:
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Satellite Cells, Skeletal Muscle*/metabolism
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Animals ; Cattle ; Ribonucleoproteins/metabolism ; Carrier Proteins/metabolism ; Muscle Development/genetics
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References:
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Contributed Indexing:
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Keywords: HNRNPA2B1; MuSCs; bovine; lncRNA; miR-206; myogenesis
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Substance Nomenclature:
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0 (RNA, Long Noncoding)
0 (Ribonucleoproteins)
0 (Carrier Proteins)
0 (MicroRNAs)
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Entry Date(s):
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Date Created: 20230413 Date Completed: 20230414 Latest Revision: 20230427
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Update Code:
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20240105
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PubMed Central ID:
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PMC10093610
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DOI:
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10.3390/cells12071028
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PMID:
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37048101
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Skeletal muscle satellite cells (MuSCs) can proliferate, differentiate, and self-renew, and can also participate in muscle formation and muscle injury repair. Long noncoding RNAs (lncRNAs) can play an important role with the RNA binding protein and microRNAs (miRNAs) to regulate the myogenesis of bovine MuSCs, however, its molecular mechanism is still being explored. In this study, differentially expressed 301 lncRNAs were identified during the myogenic differentiation of cells based on an in vitro model of induced differentiation of bovine MuSCs using RNA sequencing (RNA-seq). Based on the ability of miR-206 to regulate myogenic cell differentiation, a new kind of lncRNA-lncA2B1 without protein-coding ability was found, which is expressed in the nucleus and cytoplasm. Subsequently, lncA2B1 inhibited cell proliferation by downregulating the expression of the proliferation marker Pax7 and promoted myogenic differentiation by upregulating the expression of the differentiation marker MyHC, whose regulatory function is closely related to miR-206. By RNA pulldown/LC-MS experiments, heterogeneous ribonucleoprotein A2/B1 (HNRNPA2B1), and DExH-Box Helicase 9 (DHX9) were identified as common binding proteins of lncA2B1 and miR-206. Overexpression of lncA2B1 and miR-206 significantly upregulated the expression level of HNRNPA2B1. Downregulation of HNRNPA2B1 expression significantly decreased the expression level of the differentiation marker MyHC, which indicates that miR-206 and lncA2B1 regulate myogenic differentiation of bovine MuSCs by acting on HNRNPA2B1. This study screened and identified a novel lncRNA-lncA2B1, which functions with miR-206 to regulate myogenesis via the common binding proteins HNRNPA2B1. The results of this study provide a new way to explore the molecular mechanisms by which lncRNAs and miRNAs regulate muscle growth and development.
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