Predictors of psychoneurological symptoms in cancer caregivers over time: Role of caregiving burden, stress, and patient symptoms.

Tytuł:: Predictors of psychoneurological symptoms in cancer caregivers over time: Role of caregiving burden, stress, and patient symptoms.
Autorzy:: Litzelman K; Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin-Madison, Madison, WI, USA. .; University of Wisconsin Carbone Cancer Center, Madison, WI, USA. .
Berghoff A; Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin-Madison, Madison, WI, USA.
Stevens J; School of Nursing, University of Wisconsin-Madison, Madison, WI, USA.
Kwekkeboom K; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.; School of Nursing, University of Wisconsin-Madison, Madison, WI, USA.
Źródło:: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2023 Apr 17; Vol. 31 (5), pp. 274. Date of Electronic Publication: 2023 Apr 17.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Berlin : Springer International, c1993-
MeSH Terms:: Caregivers*
Neoplasms*/therapy
Humans ; Emotions ; Anxiety/epidemiology ; Anxiety/etiology ; Caregiver Burden
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Grant Information:: P30 CA014520 United States CA NCI NIH HHS
Contributed Indexing:: Keywords: Cancer; Caregiver burden; Caregivers; Oncology; Psychological stress; Psychoneurological symptoms
Entry Date(s):: Date Created: 20230417 Date Completed: 20230419 Latest Revision: 20240418
Update Code:: 20240418
PubMed Central ID:: PMC10230955
DOI:: 10.1007/s00520-023-07741-3
PMID:: 37067616
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Purpose: In cancer patients, stress is associated with a psychoneurologic (PN) symptom cluster of depressed mood, anxiety, pain, fatigue, and sleep disturbance. The stress of caregiving may trigger similar symptoms among caregivers and warrants investigation. The purpose of this analysis was to characterize correlates of PN symptom burden in cancer caregivers.
Methods: Cancer patient-caregiver dyads (n = 29) provided eight weekly symptom reports using a web-based survey. Primary and secondary stressors of caregiving were also assessed. Mixed models accounting for repeated measurement were used to assess the between- and within-dyad predictors of caregiver PN symptom burden. The interaction of patient PN symptom burden and stress was tested. Exploratory cross-lagged Actor-Partner Interdependence Models were used to assess the week-to-week interdependence between patient and caregiver symptoms.
Results: Caregivers most frequently reported feeling anxious (44% on average across timepoints), sleep problems (31%), fatigue (25%), and depressed mood (24%). Mixed models indicated that within dyads, greater hours of care and more patient symptoms were associated with greater caregiver PN symptom burden. Greater baseline perceived stress was also associated with higher caregiver PN symptom burden and moderated the association between patient and caregiver PN symptom burden. Cross-lagged Actor-Partner Interdependence Models indicated longitudinal interdependence among survivor and caregiver symptom burden.
Conclusions: The findings provide preliminary evidence of the interrelationship of PN symptom burden in caregivers and patients and the potential for stress to amplify this interrelationship, with implications for symptom management and supportive care practice.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Comment in: Support Care Cancer. 2023 Aug 1;31(8):502. (PMID: 37526772)

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