Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers.

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Tytuł:: Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers.
Autorzy:: Muhie S; Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; The Geneva Foundation, Silver Spring, MD 20910, USA. Electronic address: .
Gautam A; Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Yang R; Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Misganaw B; Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Vysnova Inc., Landover, MD 20785, USA.
Daigle BJ Jr; Departments of Biological Sciences and Computer Science, The University of Memphis, Memphis, TN 38152, USA.
Mellon SH; Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Flory JD; Office of Mental Health, James J. Peters VA Medical Center, Bronx, NY 10468, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10468, USA.
Abu-Amara D; Department of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA.
Lee I; Institute for Systems Biology, Seattle, WA 98109, USA.
Wang K; Institute for Systems Biology, Seattle, WA 98109, USA.
Rampersaud R; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Hood L; Institute for Systems Biology, Seattle, WA 98109, USA.
Yehuda R; Office of Mental Health, James J. Peters VA Medical Center, Bronx, NY 10468, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10468, USA.
Marmar CR; Department of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA.
Wolkowitz OM; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Ressler KJ; McLean Hospital, Belmont, MA 02478, USA; Harvard Medical School, Boston, MA 02115, USA.
Doyle FJ 3rd; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02134, USA.
Hammamieh R; Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Jett M; US Army Medical Research and Development Command, HQ, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. Electronic address: .
Corporate Authors:: PTSD Systems Biology Consortium
Źródło:: Cell reports. Medicine [Cell Rep Med] 2023 May 16; Vol. 4 (5), pp. 101045.
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Język:: English
Imprint Name(s):: Original Publication: [Cambridge, MA] : Cell Press, [2020]-
MeSH Terms:: Military Personnel*/psychology
Veterans*/psychology
Stress Disorders, Post-Traumatic*/diagnosis
Stress Disorders, Post-Traumatic*/genetics
Stress Disorders, Post-Traumatic*/psychology
Humans ; Proteomics ; Inflammation
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Contributed Indexing:: Keywords: active duty; angiogenesis; inflammatory response; metabolic dysregulation; molecular signature; multi-omics; oxidative stress; post-traumatic stress disorder; veterans; wound healing
Entry Date(s):: Date Created: 20230517 Date Completed: 20230519 Latest Revision: 20230529
Update Code:: 20240105
PubMed Central ID:: PMC10213980
DOI:: 10.1016/j.xcrm.2023.101045
PMID:: 37196634
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Post-traumatic stress disorder (PTSD) is a multisystem syndrome. Integration of systems-level multi-modal datasets can provide a molecular understanding of PTSD. Proteomic, metabolomic, and epigenomic assays are conducted on blood samples of two cohorts of well-characterized PTSD cases and controls: 340 veterans and 180 active-duty soldiers. All participants had been deployed to Iraq and/or Afghanistan and exposed to military-service-related criterion A trauma. Molecular signatures are identified from a discovery cohort of 218 veterans (109/109 PTSD+/-). Identified molecular signatures are tested in 122 separate veterans (62/60 PTSD+/-) and in 180 active-duty soldiers (PTSD+/-). Molecular profiles are computationally integrated with upstream regulators (genetic/methylation/microRNAs) and functional units (mRNAs/proteins/metabolites). Reproducible molecular features of PTSD are identified, including activated inflammation, oxidative stress, metabolic dysregulation, and impaired angiogenesis. These processes may play a role in psychiatric and physical comorbidities, including impaired repair/wound healing mechanisms and cardiovascular, metabolic, and psychiatric diseases.
Competing Interests: Declaration of interests The authors declare no competing interests
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)

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