Total Glucosides of Paeony Regulate Immune Imbalance Mediated by Dermal Mesenchymal Stem Cells in Psoriasis Mice.

Szczegóły
Abstrakt

Tytuł:: Total Glucosides of Paeony Regulate Immune Imbalance Mediated by Dermal Mesenchymal Stem Cells in Psoriasis Mice.
Autorzy:: Lei MJ; Department of Dermatology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, 050011, China.
Bai F; Department of Dermatology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, 050011, China.
Zhang QY; Department of Dermatology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, 050011, China.
Yang QQ; Department of Dermatology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, 050011, China.
Tian Z; Department of Dermatology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, 050011, China. .
Źródło:: Chinese journal of integrative medicine [Chin J Integr Med] 2023 Jun; Vol. 29 (6), pp. 517-525. Date of Electronic Publication: 2023 May 24.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2007- : Berlin : Chinese Journal of Integrated Traditional and Western Medicine Press : Springer
Original Publication: Beijing, China : Watertown, MA : Chinese Association of the Integration of Traditional and Western Medicine : China Academy of Traditional Chinese Medicine ; Distributed by Relaxing Natural Health, [2003]-
MeSH Terms:: Psoriasis*/drug therapy
Mesenchymal Stem Cells*
Paeonia*
Male ; Animals ; Mice ; Cytokines ; Glucosides/pharmacology ; Glucosides/therapeutic use ; Mice, Inbred BALB C
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Contributed Indexing:: Keywords: dermal mesenchymal stem cells; immune imbalance; inflammatory response; psoriasis; total glucosides of paeony
Substance Nomenclature:: 0 (Cytokines)
0 (Glucosides)
Entry Date(s):: Date Created: 20230524 Date Completed: 20230526 Latest Revision: 20230526
Update Code:: 20240105
DOI:: 10.1007/s11655-023-3737-y
PMID:: 37222920
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Objective: To investigate the therapeutic effects of total glucosides of paeony (TGP) on psoriasis based on the immunomodulatory effect of dermal mesenchymal stem cells (DMSCs).
Methods: A total of 30 male BALB/c mice were divided into 6 groups (n=5 in each) by a random number table method, including control, psoriasis model (model, 5% imiquimod cream 42 mg/d), low-, medium- and high-dose TGP (50, 100, and 200 mg/kg, L, M-, and H-TGP, respectively), and positive control group (2.5 mg/kg acitretin). After 14 days of continuous administration, the skin's histopathological changes, apoptosis, secretion of inflammatory cytokines, and proportion of regulatory T cells (Treg) and T helper cell 17 (Th17) were evaluated using hematoxylin-eosin (HE) staining, TdT-mediated dUTP nick end labeling staining, enzyme-linked immunosorbent assay, and flow cytometry, respectively. DMSCs were further isolated from the skin tissues of normal and psoriatic mice, and the cell morphology, phenotype, and cycle were observed. Furthermore, TGP was used to treat psoriatic DMSCs to analyze the effects on the DMSCs immune regulation.
Results: TGP alleviated skin pathological injury, reduced epidermis layer thickness, inhibited apoptosis, and regulated the secretion of inflammatory cytokines and the proportion of Treg and Th17 in the skin tissues of psoriatic mice (P<0.05 or P<0.01). There was no significant difference in cell morphology and phenotype between control and psoriatic DMSCs (P>0.05), however, more psoriatic DMSCs remained in G 0 /G 1 phase compared with the normal DMSCs (P<0.01). TGP treatment of psoriatic DMSCs significantly increased cell viability, decreased apoptosis, relieved inflammatory response, and inhibited the expression of toll-like receptor 4 and P65 (P<0.05 or P<0.01).
Conclusion: TGP may exert a good therapeutic effect on psoriasis by regulating the immune imbalance of DMSCs.
(© 2023. The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature.)

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