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Tytuł:
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Opioid-free anesthesia with lidocaine for improved postoperative recovery in hysteroscopy: a randomized controlled trial.
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Autorzy:
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Cha NH; Institute of Anesthesiology and Critical Care Medicine, Three Gorges University & Yichang Central People's Hospital, No. 183 Yiling Avenue, Wujiagang District, 443000, Yichang City, Hubei, China.
Hu Y; Institute of Anesthesiology and Critical Care Medicine, Three Gorges University & Yichang Central People's Hospital, No. 183 Yiling Avenue, Wujiagang District, 443000, Yichang City, Hubei, China.
Zhu GH; Institute of Anesthesiology and Critical Care Medicine, Three Gorges University & Yichang Central People's Hospital, No. 183 Yiling Avenue, Wujiagang District, 443000, Yichang City, Hubei, China.
Long X; Institute of Anesthesiology and Critical Care Medicine, Three Gorges University & Yichang Central People's Hospital, No. 183 Yiling Avenue, Wujiagang District, 443000, Yichang City, Hubei, China.
Jiang JJ; Institute of Anesthesiology and Critical Care Medicine, Three Gorges University & Yichang Central People's Hospital, No. 183 Yiling Avenue, Wujiagang District, 443000, Yichang City, Hubei, China.
Gong Y; Institute of Anesthesiology and Critical Care Medicine, Three Gorges University & Yichang Central People's Hospital, No. 183 Yiling Avenue, Wujiagang District, 443000, Yichang City, Hubei, China. .
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Źródło:
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BMC anesthesiology [BMC Anesthesiol] 2023 Jun 03; Vol. 23 (1), pp. 192. Date of Electronic Publication: 2023 Jun 03.
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Typ publikacji:
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Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: [London] : BioMed Central, 2001-
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MeSH Terms:
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Analgesics, Opioid*
Anesthesiology*
Humans ; Female ; Pregnancy ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Lidocaine ; Sufentanil ; Hysteroscopy ; Postoperative Nausea and Vomiting ; Anesthesia, General ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Double-Blind Method
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References:
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Anesth Essays Res. 2019 Apr-Jun;13(2):199-203. (PMID: 31198230)
Anesth Analg. 1999 Jan;88(1):83-90. (PMID: 9895071)
Anaesthesia. 1988 Mar;43(3):198-201. (PMID: 3284402)
Br J Anaesth. 2000 Jan;84(1):11-5. (PMID: 10740540)
Br J Anaesth. 2001 Apr;86(4):523-7. (PMID: 11573626)
Drugs. 2018 Aug;78(12):1229-1246. (PMID: 30117019)
Anesth Analg. 2020 Aug;131(2):411-448. (PMID: 32467512)
Curr Opin Crit Care. 2009 Feb;15(1):36-43. (PMID: 19179869)
Perioper Med (Lond). 2018 Jul 3;7:16. (PMID: 29988696)
Anesthesiology. 2021 Apr 1;134(4):541-551. (PMID: 33630043)
Best Pract Res Clin Anaesthesiol. 2019 Sep;33(3):353-360. (PMID: 31785720)
Pharmacotherapy. 2013 Apr;33(4):383-91. (PMID: 23553809)
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Contributed Indexing:
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Keywords: Opioid-free anesthesia; Opioids; Postoperative nausea and vomiting; Quality of recovery (QoR)
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Substance Nomenclature:
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0 (Analgesics, Opioid)
98PI200987 (Lidocaine)
AFE2YW0IIZ (Sufentanil)
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Entry Date(s):
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Date Created: 20230603 Date Completed: 20230605 Latest Revision: 20230614
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Update Code:
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20240105
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PubMed Central ID:
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PMC10239123
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DOI:
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10.1186/s12871-023-02152-7
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PMID:
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37270472
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Background: Anesthesia with opioids negatively affects patients' quality of recovery. Opioid-free anesthesia attempts to avoid these effects. This study aimed to evaluate the effect of opioid-free anesthesia on the quality of recovery, using lidocaine on patients undergoing hysteroscopy.
Methods: A parallel-group, randomized, double-blind, controlled trial was conducted in Yichang Central Peoples' Hospital, Hubei Province, China, from January to April, 2022. We included 90 female patients (age: 18-65 years, American Society of Anesthesiologists Physical Status Class I-II) scheduled for elective hysteroscopy, 45 of whom received lidocaine (Group L), and 45 received sufentanil (Group S). Patients were randomly allocated to receive either lidocaine or sufentanil perioperatively. The primary outcome was the quality of postoperative recovery, which was assessed using the QoR-40 questionnaire (a patient-reported outcome questionnaire measuring the quality of recovery after surgery).
Results: The two groups were similar in age, American Society of Anesthesiology physical status, height, weight, body mass index, and surgical duration. The QoR scores were significantly higher in Group L than Group S. The incidence of postoperative nausea and vomiting, as well as the time to extubation were significantly lower in Group L than Group S.
Conclusion: Opioid-free anesthesia with lidocaine achieves a better quality of recovery, faster recovery, and a shorter time to extubation than general anesthesia with sufentanil.
Trial Registration: The trial was registered on January 15, 2022 in the Chinese Clinical Trial Registry ( http://www.chictr.org.cn/showprojen.aspx?proj=149386 ), registration number ChiCTR2200055623.(15/01/2022).
(© 2023. The Author(s).)
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