Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma.

Tytuł :
Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma.
Autorzy :
Rodnan GP
Lipinski E
Luksick J
Pokaż więcej
Źródło :
Arthritis and rheumatism [Arthritis Rheum] 1979 Feb; Vol. 22 (2), pp. 130-40.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
Język :
English
Imprint Name(s) :
Publication: : Hoboken, N.J. : Wiley-Blackwell
Original Publication: Atlanta [etc.] Arthritis Foundation [etc.]
MeSH Terms :
Collagen/*metabolism
Scleroderma, Localized/*pathology
Scleroderma, Systemic/*pathology
Skin/*pathology
Acromegaly/metabolism ; Acromegaly/pathology ; Adolescent ; Adult ; Aged ; Biopsy ; Female ; Humans ; Hydroxyproline/metabolism ; Male ; Middle Aged ; Scleroderma, Localized/metabolism ; Scleroderma, Systemic/metabolism ; Skin/metabolism
Substance Nomenclature :
9007-34-5 (Collagen)
RMB44WO89X (Hydroxyproline)
Entry Date(s) :
Date Created: 19790201 Date Completed: 19790426 Latest Revision: 20190717
Update Code :
20210623
DOI :
10.1002/art.1780220205
PMID :
420706
Czasopismo naukowe
Skin biopsies of uniform location and surface area (7 mm diameter) were obtained from the extensor aspect of the forearm of 147 patients with progressive systemic sclerosis (PSS) (107 with diffuse scleroderma, 40 with the CREST syndrome variant) and 58 individuals with normal skin. After careful removal of all subcutaneous fatty tissue, the skin cores were weighed and their water and hydroxyproline content determined. Despite recent claims to the contrary, it was found that there is a marked and highly significant increase in the thickness of the skin during the indurative phase of PSS, and that this is associated with a proportionate increase in total dermal collagen content. A similar degree of thickening was found in the skin of patients with eosinophilic fasciitis and acromegaly. A close correlation was observed between clinical estimation of the degree of skin thickening and the weight of the skin biopsy cores. Change in the weight of skin cores was observed during the course of illness of the patients with PSS and may serve as a useful measurement of alteration in the degree of skin thickening.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies