Amine functions of reduced basicity. Hypoglycemic and natriuretic alpha-alkoxybenzylamidoximes, amidines, and cycloamidines.

Szczegóły

Tytuł:: Amine functions of reduced basicity. Hypoglycemic and natriuretic alpha-alkoxybenzylamidoximes, amidines, and cycloamidines.
Autorzy:: Bailey DM
DeGrazia CG
Wood D
Siggins J
Harding HR
Potts GO
Skulan TW
Źródło:: Journal of medicinal chemistry [J Med Chem] 1974 Jul; Vol. 17 (7), pp. 702-8.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Washington Dc : American Chemical Society
Original Publication: [Easton, Pa.] : American Chemical Society, [c1963-
MeSH Terms:: Amidines/*chemical synthesis
Hypoglycemic Agents/*chemical synthesis
Natriuresis/*drug effects
Amidines/pharmacology ; Amidines/toxicity ; Animals ; Blood Glucose/analysis ; Blood Pressure/drug effects ; Cats ; Codeine ; Dogs ; Haplorhini ; Hydrochlorothiazide/pharmacology ; Hypertension, Renal/metabolism ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/toxicity ; In Vitro Techniques ; Kinetics ; Lethal Dose 50 ; Male ; Mice ; Microsomes, Liver/enzymology ; Oxidoreductases, N-Demethylating/antagonists & inhibitors ; Oximes/chemical synthesis ; Oximes/pharmacology ; Oximes/toxicity ; Proadifen/pharmacology ; Rats ; Structure-Activity Relationship
Substance Nomenclature:: 0 (Amidines)
0 (Blood Glucose)
0 (Hypoglycemic Agents)
0 (Oximes)
0J48LPH2TH (Hydrochlorothiazide)
A510CA4CBT (Proadifen)
EC 1.5.- (Oxidoreductases, N-Demethylating)
UX6OWY2V7J (Codeine)
Entry Date(s):: Date Created: 19740701 Date Completed: 19740826 Latest Revision: 20201209
Update Code:: 20240104
DOI:: 10.1021/jm00253a009
PMID:: 4209582
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