Malonaldehyde in cervical mucus associated with copper IUD.

Szczegóły

Tytuł:: Malonaldehyde in cervical mucus associated with copper IUD.
Autorzy:: Bond AM
Briggs MH
Deprez PP
Jones RD
Wallace GG
Źródło:: Lancet (London, England) [Lancet] 1980 May 17; Vol. 1 (8177), pp. 1087-8.
Typ publikacji:: Letter
Język:: English
Imprint Name(s):: Publication: 2004- : London : Elsevier
Original Publication: London : J. Onwhyn
MeSH Terms:: Carcinogens/*analysis
Cervix Mucus/*analysis
Intrauterine Devices/*adverse effects
Malonates/*analysis
Malondialdehyde/*analysis
Animals ; Copper/metabolism ; Female ; Humans ; Mice
Contributed Indexing:: Indexing Agency: PIP Local ID #: 800638. Indexing Agency: POP Local ID #: 00076609.
Keywords: Biology; Cervical Mucus--analysis*; Cervix; Contraception; Contraceptive Methods--side effects; Copper*; Correlation Studies*; Family Planning; Genitalia; Genitalia, Female; Ingredients And Chemicals; Inorganic Chemicals; Iud Material; Iud--side effects*; Metals; Physiology; Research Methodology; Statistical Studies; Studies; Urogenital System; Uterus
Note: TJ: LANCET.
Local Abstract: [PIP] Malonaldehyde was measured by a colorimetric assay in the cervical mucus specimens of 19 women wearing copper IUDs and 21 women wearing inert IUDs to determine the relationship between copper biochemistry and the potential production of this potential carcinogen. Malonaldehyde was detected in 8 of the 19 specimens from women fitted with copper IUDs but in none of the inert IUD group specimens. The concentrations of the component varied, but were generally in the range of 100 nmol/gm. Based on certain assumptions about the bioreactivity of malonaldehyde, it was estimated that the daily production rate of malonaldehyde associated with copper IUD is from .1-.9 mcmol (7-93 mcg) (this is the cervical rate measurement). Though malonaldehyde is associated with pelvic inflammatory exudates, it is concluded that since the epithelium of the uterus is shed monthly during menstruation, it is unlikely that malonaldehyde associated with the copper IUD is harmful; rather it may have something to do with the copper IUDs' mechanism of action.
Substance Nomenclature:: 0 (Carcinogens)
0 (Malonates)
4Y8F71G49Q (Malondialdehyde)
789U1901C5 (Copper)
Entry Date(s):: Date Created: 19800517 Date Completed: 19800726 Latest Revision: 20190611
Update Code:: 20240104
DOI:: 10.1016/s0140-6736(80)91530-5
PMID:: 6103422
: Opinia redakcyjna

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