Sporadic ALS/MND: a global neurodegeneration with retroviral involvement?

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Tytuł:: Sporadic ALS/MND: a global neurodegeneration with retroviral involvement?
Autorzy:: Westarp ME; Department of Neurology, University of Ulm, Germany.
Ferrante P
Perron H
Bartmann P
Kornhuber HH
Źródło:: Journal of the neurological sciences [J Neurol Sci] 1995 May; Vol. 129 Suppl, pp. 145-7.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Amsterdam : Elsevier, <19 ->
MeSH Terms:: Amyotrophic Lateral Sclerosis/*pathology
Amyotrophic Lateral Sclerosis/*virology
Motor Neuron Disease/*pathology
Motor Neuron Disease/*virology
Nerve Degeneration/*physiology
Retroviridae Infections/*pathology
Retroviridae Infections/*virology
Slow Virus Diseases/*pathology
Slow Virus Diseases/*virology
Adult ; Aged ; Antigens, Viral/analysis ; HIV-1/immunology ; HIV-2/immunology ; Human T-lymphotropic virus 1/immunology ; Humans ; Immunoblotting ; Immunoglobulin G/analysis ; Middle Aged
Substance Nomenclature:: 0 (Antigens, Viral)
0 (Immunoglobulin G)
Entry Date(s):: Date Created: 19950501 Date Completed: 19951124 Latest Revision: 20190724
Update Code:: 20240104
DOI:: 10.1016/0022-510x(95)00087-i
PMID:: 7595609
: Czasopismo naukowe

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Sporadic amyotrophic lateral sclerosis may be an aetiologically heterogenous disease. We confirmed elevated circulating IgG immune complexes, and altered IgG seroreactivities against human retroviral antigens (HIV-2 and HTLV immunoblots) in overlapping subgroups of patients. Together with preliminary findings of a positive polymerase chain reactivity for human T-lymphotropic virus (HTLV.tax/rex) in blood leukocytes of 5 out of 14 sALS patients, we interpret this as evidence for a retroviral involvement in this relentlessly progressive, often asymmetrically spreading neurodegeneration. The possibility of a secondary phenomenon seems unlikely, yet cannot be completely ruled out.

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