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Tytuł pozycji:

The effect of gadolinium on the sensitivity and specificity of MR in the initial diagnosis of multiple sclerosis.

Tytuł:
The effect of gadolinium on the sensitivity and specificity of MR in the initial diagnosis of multiple sclerosis.
Autorzy:
Tas MW; Department of Diagnostic Radiology, Free University Hospital, Amsterdam, The Netherlands.
Barkhol F
van Walderveen MA
Polman CH
Hommes OR
Valk J
Źródło:
AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 1995 Feb; Vol. 16 (2), pp. 259-64.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: Oak Brook, IL : American Society of Neuroradiology
Original Publication: Baltimore, Williams & Wilkins.
MeSH Terms:
Contrast Media*
Magnetic Resonance Imaging*
Meglumine*
Organometallic Compounds*
Multiple Sclerosis/*diagnosis
Pentetic Acid/*analogs & derivatives
Adult ; Brain/pathology ; Drug Combinations ; Female ; Gadolinium DTPA ; Humans ; Male ; Middle Aged ; Prospective Studies ; Sensitivity and Specificity
Substance Nomenclature:
0 (Contrast Media)
0 (Drug Combinations)
0 (Organometallic Compounds)
6HG8UB2MUY (Meglumine)
7A314HQM0I (Pentetic Acid)
K2I13DR72L (Gadolinium DTPA)
Entry Date(s):
Date Created: 19950201 Date Completed: 19950523 Latest Revision: 20210806
Update Code:
20240104
PubMed Central ID:
PMC8338347
PMID:
7726070
Czasopismo naukowe
Purpose: To determine whether gadolinium can improve the sensitivity and specificity of MR imaging for the initial diagnosis of multiple sclerosis.
Methods: Patients (n = 57) with neurologic symptoms suggesting multiple sclerosis were studied prospectively. MR imaging consisted of T2-weighted and gadolinium-enhanced T1-weighted spin-echo images. Lumbar puncture was performed for cerebrospinal fluid analysis in 34 patients.
Results: After imaging, 17 patients (35%) had clinically definite multiple sclerosis. Cerebrospinal fluid examination had a sensitivity of 69% and specificity of 38%. Using liberal criteria, the sensitivity of T2-weighted MR imaging was 94% and the specificity 55%; using more strict criteria, the specificity increased to 65% with a sensitivity of 88%. Gadopentetate dimeglumine enhancement increased the specificity further to 80% with a loss of sensitivity (59%).
Conclusion: Gadolinium enhancement increases the specificity of MR imaging in the early diagnosis of multiple sclerosis.

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