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Tytuł pozycji:

Iodine deficiency induces thyroid autoimmune reactivity in Wistar rats.

Tytuł:
Iodine deficiency induces thyroid autoimmune reactivity in Wistar rats.
Autorzy:
Mooij P; Department of Immunology, Erasmus University, Rotterdam, The Netherlands.
de Wit HJ
Bloot AM
Wilders-Truschnig MM
Drexhage HA
Źródło:
Endocrinology [Endocrinology] 1993 Sep; Vol. 133 (3), pp. 1197-204.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: 2017- : New York : Oxford University Press
Original Publication: Los Angeles, Calif. : Association for the Study of Internal Secretions,
MeSH Terms:
Autoimmune Diseases/*chemically induced
Iodine/*deficiency
Thyroid Diseases/*immunology
Animals ; Autoantibodies/biosynthesis ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD8 Antigens/analysis ; Diet ; Female ; Goiter/etiology ; Iodine/administration & dosage ; Iodine/urine ; Leukocyte Count ; Lymphocytes/immunology ; Lymphocytes/pathology ; Organ Size ; Rats ; Rats, Wistar ; Thyroid Diseases/chemically induced ; Thyroid Gland/immunology ; Thyroid Gland/pathology
Substance Nomenclature:
0 (Autoantibodies)
0 (CD8 Antigens)
9679TC07X4 (Iodine)
Entry Date(s):
Date Created: 19930901 Date Completed: 19931006 Latest Revision: 20171116
Update Code:
20240104
DOI:
10.1210/endo.133.3.8103449
PMID:
8103449
Czasopismo naukowe
The last 2 decades it has become clear that iodine deficiency has a modulating effect on the thyroid autoimmune response in humans. Also, in animals that spontaneously develop autoimmune thyroid disease, evidence is accumulating that a low iodine intake can modulate thyroid autoimmune reactivity. However, it is still not clear what the effect of a low iodine intake on thyroid autoimmune reactivity is in normal nonautoimmune animals. To study the relationship of a dietary low iodine intake on the thyroid autoimmune reactivity in nonautoimmune animals, normal Wistar rats (female) were kept on an enriched iodine diet (daily iodine intake of 100 micrograms iodine), a "for our area normal" (conventional) diet (COD; daily iodine intake of 7 micrograms iodine), a low iodine diet (LID; 2 days of 1% KCLO4, followed by iodine-deficient drinking water/pellets), or an extremely low iodine diet (LID+; 1% KCLO4 continuously in the drinking water and iodine-deficient pellets). The enriched iodine diet rats were euthyroid (T3, approximately 8 nM/liter: T4, approximately 50 nM/liter; TSH, approximately 2 ng/ml), had a normal thyroid weight (approximately 12.5 mg), and showed only minimal signs of local thyroid immune reactivity; low numbers of intrathyroidal dendritic cells (DC; approximately 35 DC/mm2), CD4+ cells (approximately 2 cells/mm2), and CD8+ cells (approximately 2.5 cells/mm2) were found in combination with low anticolloid antibody production (incidence of positive animals, 12.5%). The COD resulted in a normal thyroid function. The rats were euthyroid (range of T3, 1.6-1.2 nM/liter; T4, approximately 50 nM/liter; TSH, approximately 2 ng/ml) and had a normal thyroid weight (approximately 12.5 mg). However, some signs of thyroid autoimmune reactivity were found [number of intrathyroidal DC, approximately 40/mm2; approximately 3 CD4-positive (CD+) cells/mm2; approximately 3 CD8+ cells/mm2; together with a 30% incidence of anticolloid antibodies]. The LID and LID+ not only induced goiter formation [thyroid weight, 27.3 +/- 4.2 mg (mean +/- SD) after 12 weeks of LID and 38.4 +/- 5.3 mg after 4 weeks of LID+] and low production of T4 by the thyroid [28 +/- 3 nM/liter (mean +/- SD)] after 12 weeks of LID and 14 +/- 3 nM/liter after 2 weeks of LID+], but also induced various signs of thyroid autoimmune reactivity.(ABSTRACT TRUNCATED AT 400 WORDS)

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