[Neuropsychiatric symptoms in vitamin B12 deficiency and microcarcinoidosis. The complications of chronic atrophic gastritis].

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Abstrakt

Tytuł:: [Neuropsychiatric symptoms in vitamin B12 deficiency and microcarcinoidosis. The complications of chronic atrophic gastritis].
Autorzy:: Ossege LM; Neurologische Klinik, Universität Münster.
Pohle T
Müller KM
May B
Malin JP
Transliterated Title:: Neuro-psychiatrische Symptome bei Vitamin-B12-Mangel und Mikrokarzinoidose. Komplikationen einer chronischen atrophischen Gastritis.
Źródło:: Deutsche medizinische Wochenschrift (1946) [Dtsch Med Wochenschr] 1996 Jun 07; Vol. 121 (23), pp. 758-62.
Typ publikacji:: Case Reports; English Abstract; Journal Article; Review
Język:: German
Imprint Name(s):: Original Publication: Stuttgart [etc.] : G. Thieme, 1946-
MeSH Terms:: Carcinoid Tumor/*etiology
Gastritis, Atrophic/*complications
Memory Disorders/*etiology
Nervous System Diseases/*etiology
Stomach Neoplasms/*etiology
Vitamin B 12 Deficiency/*complications
Aged ; Carcinoid Tumor/complications ; Carcinoid Tumor/diagnosis ; Carcinoid Tumor/psychology ; Chronic Disease ; Female ; Gastritis, Atrophic/diagnosis ; Gastritis, Atrophic/psychology ; Hematinics/administration & dosage ; Humans ; Memory Disorders/diagnosis ; Memory Disorders/psychology ; Nervous System Diseases/diagnosis ; Nervous System Diseases/psychology ; Psychopathology ; Stomach Neoplasms/complications ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/psychology ; Vitamin B 12/administration & dosage ; Vitamin B 12 Deficiency/diagnosis ; Vitamin B 12 Deficiency/drug therapy ; Vitamin B 12 Deficiency/etiology ; Vitamin B 12 Deficiency/psychology
Liczba referencji:: 25
Substance Nomenclature:: 0 (Hematinics)
P6YC3EG204 (Vitamin B 12)
Entry Date(s):: Date Created: 19960607 Date Completed: 19960723 Latest Revision: 20131121
Update Code:: 20240104
DOI:: 10.1055/s-2007-1024559
PMID:: 8646993
: Czasopismo naukowe

History and Findings: A 69-year-old woman reported marked restriction of voluntary movements of the hands in the preceding 6 months. She had also experienced loss of motivation, memory and concentration. Her skin was pale yellow, and scratches on her skin indicated marked pruritus.
Investigations: Neurological examination revealed decreased vibratory sense in both legs. Haemoglobin concentration was 8.3 g/dl, mean corpuscular volume 114 fl, vitamin B12 level < 100 ng/l, folic acid level normal. Antibody titre against parietal cells was increased, vitamin B12 resorption diminished. Gastroscopy revealed small raised lesions, made up of hyperplastic cells which stained with chromogranin, indicating a diagnosis of microcarcinoid of the gastric mucosa.
Treatment and Course: On administration of cobalamine (1,000 micrograms i.m. daily for 2 weeks, twice weekly for 6 weeks, then once per week for the last 7 months) the blood picture returned to normal, but the microcarcinoids, the psychological symptoms and the apraxia of the hands were unchanged.

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