Antiplatelet of vasorelaxing actions of some benzylisoquinoline and phenanthrene alkaloids.

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Tytuł:: Antiplatelet of vasorelaxing actions of some benzylisoquinoline and phenanthrene alkaloids.
Autorzy:: Chen KS; Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
Ko FN
Teng CM
Wu YC
Źródło:: Journal of natural products [J Nat Prod] 1996 May; Vol. 59 (5), pp. 531-4.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Cincinnati, American Society of Pharmacognosy.
MeSH Terms:: Alkaloids/*isolation & purification
Platelet Aggregation Inhibitors/*isolation & purification
Vasodilator Agents/*isolation & purification
Alkaloids/pharmacology ; Animals ; Aorta, Thoracic/drug effects ; Female ; In Vitro Techniques ; Muscle Relaxation/drug effects ; Muscle, Smooth, Vascular/drug effects ; Platelet Aggregation Inhibitors/pharmacology ; Rabbits ; Rats ; Vasodilator Agents/pharmacology
Substance Nomenclature:: 0 (Alkaloids)
0 (Platelet Aggregation Inhibitors)
0 (Vasodilator Agents)
Entry Date(s):: Date Created: 19960501 Date Completed: 19960917 Latest Revision: 20141120
Update Code:: 20240104
DOI:: 10.1021/np960354x
PMID:: 8778245
: Czasopismo naukowe

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Members of a series of benzylisoquinoline and phenanthrene alkaloids were tested for their antiplatelet and vasorelaxing actions. Atherosperminine HClO4 (15) and atherosperminium I (16) showed strong inhibition of adenosine 5'-diphosphate-induced platelet aggregation. dl-N-Methylcoclaurine (1), dl-coclaurine (6), 15, 16, xylopine hydroxylamine (18), and atherosperminine N-oxide (19) showed strong inhibition of arachidonic acid-induced platelet aggregation. Compounds 1, 15, 16, dicentrine methine (17), 18, and 19 showed strong inhibition of collagen-induced platelet aggregation. d-(-)-Magnocurarine I (8), 15, and 16 showed strong inhibition of platelet-activating factor-induced platelet aggregation. Compounds 15, 17, and 19 showed vasorelaxing action in rat thoracic aorta.

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