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Tytuł pozycji:

Plasma monoamine metabolites and spontaneous recurrence of methamphetamine-induced paranoid-hallucinatory psychosis: relation of noradrenergic activity to the occurrence of flashbacks.

Tytuł:
Plasma monoamine metabolites and spontaneous recurrence of methamphetamine-induced paranoid-hallucinatory psychosis: relation of noradrenergic activity to the occurrence of flashbacks.
Autorzy:
Yui K; Medical Care Section, Urawa Juvenile Classification Home, Ministry of Justice, Japan.
Goto K
Ikemoto S
Ishiguro T
Źródło:
Psychiatry research [Psychiatry Res] 1996 Jul 31; Vol. 63 (2-3), pp. 93-107.
Typ publikacji:
Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial
Język:
English
Imprint Name(s):
Publication: Limerick : Elsevier/North-Holland Biomedical Press
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
MeSH Terms:
Dopamine/*blood
Hallucinations/*psychology
Methamphetamine/*adverse effects
Methoxyhydroxyphenylglycol/*blood
Neurotransmitter Agents/*blood
Norepinephrine/*blood
Paranoid Disorders/*etiology
Serotonin/*blood
Adult ; Antipsychotic Agents/therapeutic use ; Female ; Hallucinations/drug therapy ; Homovanillic Acid/blood ; Humans ; Middle Aged ; Paranoid Disorders/drug therapy ; Paranoid Disorders/psychology ; Prisoners/psychology ; Recurrence ; Substance-Related Disorders/complications
Substance Nomenclature:
0 (Antipsychotic Agents)
0 (Neurotransmitter Agents)
333DO1RDJY (Serotonin)
44RAL3456C (Methamphetamine)
534-82-7 (Methoxyhydroxyphenylglycol)
VTD58H1Z2X (Dopamine)
X4W3ENH1CV (Norepinephrine)
X77S6GMS36 (Homovanillic Acid)
Entry Date(s):
Date Created: 19960731 Date Completed: 19970116 Latest Revision: 20190826
Update Code:
20240104
DOI:
10.1016/0165-1781(96)02858-2
PMID:
8878306
Czasopismo naukowe
The relationship between monoamine neurotransmitter function and spontaneous recurrence of methamphetamine (MAP) psychosis, a phenomenon known as flashbacks, was studied in a group of incarcerated women. Plasma levels of norepinephrine (NE), dopamine, 5-hydroxytryptamine, and their respective metabolites were assayed in 28 flashbackers, 19 non-flashbackers with a history of previous MAP psychosis, and 9 subjects with persistent MAP psychosis. Control data were available from 61 physically healthy prisoners (41 MAP users and 20 non-users, none of whom became psychotic). The plasma NE levels of the 28 flashbackers during flashbacks were significantly higher than levels during periods of normality, and were significantly higher than those in the MAP user and non-user controls. Plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels during flashbacks were significantly higher than those in the user controls. The nine subjects with persistent MAP psychosis had significantly higher NE levels than the user and non-user controls. The 19 non-flashbackers had significantly higher MHPG levels than the user controls. Plasma levels of 3-methoxytyramine and dihydroxyphenylacetic acid contributed to the NE levels in the flashbackers, in contrast to the findings in the control group. Noradrenergic systems may be compromised in the flashbackers, suggesting increased vulnerability to psychotic decompensation. These findings suggest that aggravation in peripheral noradrenergic hyperactivity may be an important factor in the occurrence of flashbacks.

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