Bioactive alkaloids from Illigera luzonensis.

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Tytuł:: Bioactive alkaloids from Illigera luzonensis.
Autorzy:: Chen KS; Ta-Jen Pharmaceutical Junior College, Taiwan, Republic of China.
Wu YC
Teng CM
Ko FN
Wu TS
Źródło:: Journal of natural products [J Nat Prod] 1997 Jun; Vol. 60 (6), pp. 645-7.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Cincinnati, American Society of Pharmacognosy.
MeSH Terms:: Alkaloids/*isolation & purification
Plants, Medicinal/*chemistry
Platelet Aggregation Inhibitors/*isolation & purification
Alkaloids/pharmacology ; Animals ; In Vitro Techniques ; Muscle Contraction/drug effects ; Muscle, Smooth, Vascular/drug effects ; Plant Stems/chemistry ; Platelet Aggregation Inhibitors/pharmacology ; Rabbits ; Rats
Substance Nomenclature:: 0 (Alkaloids)
0 (Platelet Aggregation Inhibitors)
Entry Date(s):: Date Created: 19970601 Date Completed: 19970915 Latest Revision: 20141120
Update Code:: 20240104
DOI:: 10.1021/np9700735
PMID:: 9214740
: Czasopismo naukowe

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Using antiplatelet aggregation as a guide to fractionation, seven aporphines, actinodaphnine (1), N-methylactinodaphnine (2), launobine (3), dicentrine (4), O-methylbulbocapnine (5), hernovine (7), and bulbocapnine (9), and two oxoaporphines, dicentrinone (6) and liriodenine (8), were isolated from the stems of Illigera luzonensis. Among them, compounds 2, 4, 5, 8, and 9 were isolated for the first time from this species. Moreover, compounds 1-5, and 8 showed significant antiplatelet aggregation and compounds 1 and 6 exhibited significant vasorelaxant activities, respectively.

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