Mapping FRA11A, a folate-sensitive fragile site in human chromosome band 11q13.3.

Szczegóły
Abstrakt

Tytuł:: Mapping FRA11A, a folate-sensitive fragile site in human chromosome band 11q13.3.
Autorzy:: Perucca-Lostanlen D; Instabilité et Altérations des Génomes, CNRS/UNSA UMR 6549, Nice, France. />Hecht BK
Courseaux A
Grosgeorge J
Hecht F
Gaudray P
Źródło:: Cytogenetics and cell genetics [Cytogenet Cell Genet] 1997; Vol. 79 (1-2), pp. 88-91.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Basel : Karger
Original Publication: Basel, New York, Karger.
MeSH Terms:: Chromosome Fragility*
Chromosome Mapping*
Chromosomes, Human, Pair 11/*drug effects
Folic Acid/*pharmacology
Hematinics/*pharmacology
Cells, Cultured ; Centromere/genetics ; Chromosome Fragile Sites ; Chromosomes, Artificial, Yeast ; Cosmids ; Humans ; In Situ Hybridization, Fluorescence ; Telomere/genetics
Substance Nomenclature:: 0 (Hematinics)
935E97BOY8 (Folic Acid)
Entry Date(s):: Date Created: 19970101 Date Completed: 19980422 Latest Revision: 20180214
Update Code:: 20240104
DOI:: 10.1159/000134689
PMID:: 9533019
: Czasopismo naukowe

FRA11A, a rare folate-sensitive fragile site assigned to 11q13.3, lies in an area of genomic instability associated with several diseases and amplification events. To map FRA11A, we used fluorescence in situ hybridization with yeast artificial chromosome and cosmid probes on metaphase chromosomes of patients expressing the fragile site. FRA11A was found situated centromeric to ACTN3 and telomeric to D11S913, these markers being within an interval of approximately 1 Mb in the 11q13.3 region.

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