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Tytuł pozycji:

[Obstructive ischemic involvement of the anterior descending coronary artery in asymmetrical septal form of hypertrophic cardiomyopathy].

Tytuł:
[Obstructive ischemic involvement of the anterior descending coronary artery in asymmetrical septal form of hypertrophic cardiomyopathy].
Autorzy:
Albanesi Filho FM; Universidade do Estado do Rio de Janeiro.
Castier MB
da Silva TT
Boghossian SH
Ginefra P
Transliterated Title:
O acometimento isquêmico obstrutivo na cardiomiopatia hipertrófica do tipo septal assimétrico com envolvimento da artéria descendente anterior.
Źródło:
Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 1997 Nov; Vol. 69 (5), pp. 309-15.
Typ publikacji:
English Abstract; Journal Article
Język:
Portuguese
Imprint Name(s):
Original Publication: Sao Paulo : Sociedad Brasileira De Cardiologia
MeSH Terms:
Cardiomyopathy, Hypertrophic/*complications
Coronary Vessels/*pathology
Myocardial Ischemia/*complications
Aged ; Cardiomyopathy, Hypertrophic/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Myocardial Ischemia/diagnosis
Entry Date(s):
Date Created: 19980603 Date Completed: 19980813 Latest Revision: 20061115
Update Code:
20240104
PMID:
9608997
Czasopismo naukowe
Purpose: The significance of necrosis and fibrosis of the interventricular septum in hypertrophic cardiomyopathy (HCM) is controversial. The purpose of this study was then to evaluate the clinical impact of left anterior descending artery (LAD) disease in HCM.
Methods: Among 158 patients presenting with HCM, 6 (3.79%) had LAD disease. Mean age was 65.16 years (52 to 70), 4 were men and 4 had the obstructive form of HCM. All patients were submitted to complete clinical and laboratory evaluation. Mean time of the diagnosis was 141 months (ranging from 78 to 182) for HCM and 42 months (ranging from one day to 106 months) for LAD disease.
Results: Five patients had unstable angina and one had myocardial infarction. LAD disease (60 to 100% coronary narrowing) was present in all patients; one patient had single vessel disease and 5 multivessel disease. During follow-up, 3 patients had coronary artery bypass grafting (CABG), one with associated septal myectomy; one was submitted to coronary angioplasty and 2 were submitted to medical treatment. During a follow-up period ranging from 76 to 124 months after LAD disease diagnosis, one patient died. At the end of the study, a reduction of the thickness of the interventricular septum from 1.53 to 1.40 cm was observed and left ventricular outflow pressure gradient decreased from 56 to 16 mmHg. Left ventricular diastolic diameter increased from 4.55 to 4.85 cm and systolic diameter from 2.83 to 3.13 cm. Left atrium diameter was unchanged.
Conclusion: LAD disease is well tolerated in the asymmetrical form of HCM and may contribute to septal fibrosis, improving cardiac function. It does not represent an adverse factor in the evolution of HCM.

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