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Tytuł pozycji:

Detecting new lesion formation in multiple sclerosis: the relative contributions of monthly dual-echo and T1-weighted scans after triple-dose gadolinium.

Tytuł :
Detecting new lesion formation in multiple sclerosis: the relative contributions of monthly dual-echo and T1-weighted scans after triple-dose gadolinium.
Autorzy :
Filippi M; Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
Mastronardo G
Rocca MA
Capra R
Gasperini C
Rovaris M
Bastianello S
Comi G
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Źródło :
European neurology [Eur Neurol] 1998 Oct; Vol. 40 (3), pp. 146-50.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: Basel, New York, Karger.
MeSH Terms :
Brain/*pathology
Multiple Sclerosis/*diagnosis
Adult ; Female ; Follow-Up Studies ; Gadolinium ; Humans ; Magnetic Resonance Imaging ; Male ; Radiopharmaceuticals
Substance Nomenclature :
0 (Radiopharmaceuticals)
AU0V1LM3JT (Gadolinium)
Entry Date(s) :
Date Created: 19980928 Date Completed: 19990216 Latest Revision: 20180213
Update Code :
20210210
DOI :
10.1159/000007971
PMID :
9748672
Czasopismo naukowe
In this study, we evaluated the frequency of formation of new lesions on brain magnetic resonance imaging (MRI) from patients with relapsing-remitting multiple sclerosis (MS) and defined the relative contributions of unenhanced and enhanced MRI. Every 4 weeks for 3 months, dual-echo and postcontrast T1-weighted (5 min after the injection of 0.3 mmol/kg gadolinium-DTPA) scans were obtained from 28 patients with relapsing-remitting MS. New lesions were defined as those present on dual-echo and/or postcontrast T1-weighted scans but with no corresponding MRI abnormalities on any of the preceding scans. A total of 111 newly formed lesions were detected during the follow-up on dual-echo and postcontrast T1-weighted scans (i.e., an average of 1.3 lesions per patient per month). Ninety-eight (88%) of such lesions were seen on both dual-echo and postcontrast T1-weighted scans, whilst 13 (12%) were seen only with one of the two techniques: 9 only on dual-echo and 4 only on postcontrast scans. Five of the 98 new lesions seen by both techniques were seen by postcontrast scans 1 month before their appearance on dual-echo scans. Our study suggests that both dual-echo and postcontrast T1-weighted scans are useful to detect newly formed lesions in patients with MS. This is of importance when using MRI to monitor the efficacy of treatments which may halt MS lesion formation.

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