[Role of cytokines in the pathogenesis of gastrointestinal diseases associated with Helicobacter pylori infection].

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Abstrakt

Tytuł:: [Role of cytokines in the pathogenesis of gastrointestinal diseases associated with Helicobacter pylori infection].
Autorzy:: Imanishi J; Département de Microbiologie, Université Médicale de la Préfecture de Kyoto, Japon.
Kita M
Yamaoka Y
Sawai N
Tanahashi T
Kodama T
Transliterated Title:: Le rôle des cytokines dans la pathogénèse des maladies gastro-intestinales associées à l'infection par Helicobacter pylori.
Źródło:: Comptes rendus des seances de la Societe de biologie et de ses filiales [C R Seances Soc Biol Fil] 1998; Vol. 192 (5), pp. 991-6.
Typ publikacji:: Journal Article
Język:: French
Imprint Name(s):: Original Publication: Paris, Masson.
MeSH Terms:: Antigens, Bacterial*
Helicobacter pylori*/genetics
Cytokines/*physiology
Gastrointestinal Diseases/*physiopathology
Helicobacter Infections/*physiopathology
Anti-Bacterial Agents/therapeutic use ; Bacterial Proteins/genetics ; Duodenal Ulcer/microbiology ; Duodenal Ulcer/physiopathology ; Gastrointestinal Diseases/microbiology ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Humans ; Interleukin-8/genetics ; Stomach Ulcer/microbiology ; Stomach Ulcer/physiopathology
Substance Nomenclature:: 0 (Anti-Bacterial Agents)
0 (Antigens, Bacterial)
0 (Bacterial Proteins)
0 (Cytokines)
0 (Interleukin-8)
0 (cagA protein, Helicobacter pylori)
Entry Date(s):: Date Created: 19990101 Date Completed: 19990128 Latest Revision: 20201209
Update Code:: 20240104
PMID:: 9871810
: Czasopismo naukowe

It is well known that Helicobacter pylori can cause gastritis, gastroduodenal ulcers and malignant diseases. The infiltration of polymorphonuclear leukocytes is recognized in the lesions of these diseases, and the infiltration disappears by antibiotic therapy. However, it is not yet clarified how Helicobacter pylori induces the formation of lesions including leukocyte infiltration. Recently, we have confirmed that several kinds of cytokines are expressed in the gastric biopsy specimens of gastroduodenal diseases. Especially, it is conjectured that chemokines such as interleukin-8 (IL-8) which are expressed in the specimens, induce leukocyte infiltration, gastric mucosal inflammation and gastroduodenal ulcers. It is possible that Helicobacter pylori CagA gene is closely related with IL-8 expression because this cytokine is more strongly expressed in the specimens from the patients infected with CagA-positive Helicobacter than those with CagA-negative one.

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