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Tytuł pozycji:

Insulin secretory patterns and blood glucose homeostasis after islet allotransplantation in IDDM patients: comparison with segmental- or whole-pancreas transplanted patients through a long term longitudinal study.

Tytuł:
Insulin secretory patterns and blood glucose homeostasis after islet allotransplantation in IDDM patients: comparison with segmental- or whole-pancreas transplanted patients through a long term longitudinal study.
Autorzy:
Secchi A; Department of Internal Medicine, Scientific Institute H San Raffaele, University of Milan, Milano, Italy.
Taglietti MV
Socci C
Maffi P
Falqui L
Caldara R
Di Carlo V
Pozza G
Źródło:
Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 1999 Jan; Vol. 77 (1), pp. 133-9.
Typ publikacji:
Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: Berlin : Springer International
Original Publication: Berlin : Springer, c1994-
MeSH Terms:
Islets of Langerhans Transplantation*
Pancreas Transplantation*
Blood Glucose/*metabolism
Diabetes Mellitus, Type 1/*surgery
Insulin/*metabolism
Adult ; Arginine ; Diabetes Mellitus, Type 1/metabolism ; Female ; Glucose Tolerance Test ; Humans ; Insulin/blood ; Insulin Secretion ; Longitudinal Studies ; Male ; Transplantation, Homologous
Substance Nomenclature:
0 (Blood Glucose)
0 (Insulin)
94ZLA3W45F (Arginine)
Entry Date(s):
Date Created: 19990204 Date Completed: 19990819 Latest Revision: 20191102
Update Code:
20240104
DOI:
10.1007/s001090050321
PMID:
9930948
Czasopismo naukowe
IDDM patients undergoing islet, segmental pancreas or whole pancreas allotransplantation were studied at regular intervals after surgery (3-6 months, 1, 2, 3 and 4 years) to evaluate glycometabolic control (24 h metabolic profile, OGTT) and serum free insulin response to insulinogenic stimuli (arginine, IVGTT). Patients received the same immunosuppressive therapy, based on cyclosporin, steroids and azathioprine. Islet transplanted patients showed: 1) an early peak of insulin secretion after arginine, that was maintained up to 4 years; 2) an early, but low peak of insulin secretion after IVGTT, which was lost at 3 years, despite evidence that islets were still functioning (insulin independence with normal HbAlc levels); 3) a diabetic-like response to OGTT at 3 months, which improved at 2 years (IGT response); 4) fasting euglycemia with mild and reversible post-prandial hyperglycemia during the 24 h metabolic profile, which was maintained for up to 2 years. Insulin secretory patterns of islet transplanted patients were similar to segmental pancreas transplanted patients, and lower than whole pancreas transplanted patients. The reduced beta cell mass transplanted and the functional denervation of the transplanted islets seem to be the major determinants of this behaviour.

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