Expression of macrophage colony-stimulating factor, scavenger receptors, and macrophage proliferation in the pregnant mouse uterus.

Szczegóły
Abstrakt

Tytuł:: Expression of macrophage colony-stimulating factor, scavenger receptors, and macrophage proliferation in the pregnant mouse uterus.
Autorzy:: Kyaw Y; Second Department of Pathology, Niigata University School of Medicine, Japan. />Hasegawa G
Takatsuka H
Shimada-Hiratsuka M
Umezu H
Arakawa M
Naito M
Źródło:: Archives of histology and cytology [Arch Histol Cytol] 1998 Dec; Vol. 61 (5), pp. 383-93.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Niigata, Japan : Japan Society of Histological Documentation, c1988-
MeSH Terms:: Cell Division*
Membrane Proteins*
Receptors, Lipoprotein*
Macrophage Colony-Stimulating Factor/*genetics
Macrophages/*cytology
Receptors, Immunologic/*genetics
Uterus/*metabolism
Animals ; Apoptosis ; CD36 Antigens ; Chemokine CCL2/genetics ; Chemokine CCL3 ; Chemokine CCL4 ; Endometrium/metabolism ; Epithelial Cells/metabolism ; Female ; Immunohistochemistry ; In Situ Hybridization ; Macrophage Inflammatory Proteins/genetics ; Mice ; Mice, Inbred BALB C ; Pregnancy ; RNA, Messenger/metabolism ; Receptors, Scavenger ; Reverse Transcriptase Polymerase Chain Reaction ; Scavenger Receptors, Class A ; Scavenger Receptors, Class B ; Scavenger Receptors, Class C ; Uterus/cytology
Substance Nomenclature:: 0 (CD36 Antigens)
0 (Chemokine CCL2)
0 (Chemokine CCL3)
0 (Chemokine CCL4)
0 (Macrophage Inflammatory Proteins)
0 (Membrane Proteins)
0 (RNA, Messenger)
0 (Receptors, Immunologic)
0 (Receptors, Lipoprotein)
0 (Receptors, Scavenger)
0 (Scarb1 protein, mouse)
0 (Scavenger Receptors, Class A)
0 (Scavenger Receptors, Class B)
0 (Scavenger Receptors, Class C)
81627-83-0 (Macrophage Colony-Stimulating Factor)
Entry Date(s):: Date Created: 19990217 Date Completed: 19990225 Latest Revision: 20191024
Update Code:: 20240104
DOI:: 10.1679/aohc.61.383
PMID:: 9990422
: Czasopismo naukowe

During pregnancy, mouse uterine epithelial cells produce and secrete a large amount of macrophage colony-stimulating factor (M-CSF/CSF-1). Macrophages accumulate and proliferate in the undecidualized endometrium of the pregnant uterus. Observations showed that macrophages expressed scavenger receptor class A (type I and type II) and class C (macrosialin). Scavenger receptors appeared to be involved in the removal of apoptotic cells in the degenerated decidual tissue. The expression of class A and class C scavenger receptor mRNAs in the uterus of pregnant mice was elevated but the expression of class B scavenger receptor (CD36) mRNA was similar to that of non-pregnant mice. The expression of various cytokines and chemokines, including M-CSF, monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1-alpha), was enhanced in the uterus of pregnant mice, suggesting that these molecules regulate macrophage chemotaxis and immunological function in the uterus. These findings imply that the pregnant uterus provides a microenvironment for the recruitment, differentiation, and proliferation of macrophages and the regulation of scavenger receptor and cytokine expression for a successful pregnancy.

Informacja