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Tytuł pozycji:

Duration of antiviral immunity after smallpox vaccination.

Tytuł :
Duration of antiviral immunity after smallpox vaccination.
Autorzy :
Hammarlund, Erika
Lewis, Matthew W.
Hansen, Scott G.
Strelow, Lisa I.
Nelson, Jay A.
Sexton, Gary J.
Hanifin, Jon M.
Slifka, Mark K.
Pokaż więcej
Temat :
SMALLPOX vaccines
ANTIVIRAL agents
CELLULAR immunity
Źródło :
Nature Medicine; Sep2003, Vol. 9 Issue 9, p1131-1137, 7p
Czasopismo naukowe
Although naturally occurring smallpox was eliminated through the efforts of the World Health Organization Global Eradication Program, it remains possible that smallpox could be intentionally released. Here we examine the magnitude and duration of antiviral immunity induced by one or more smallpox vaccinations. We found that more than 90% of volunteers vaccinated 25-75 years ago still maintain substantial humoral or cellular immunity (or both) against vaccinia, the virus used to vaccinate against smallpox. Antiviral antibody responses remained stable between 1-75 years after vaccination, whereas antiviral T-cell responses declined slowly, with a half-life of 8-15 years. If these levels of immunity are considered to be at least partially protective, then the morbidity and mortality associated with an intentional smallpox outbreak would be substantially reduced because of preexisting immunity in a large number of previously vaccinated individuals. [ABSTRACT FROM AUTHOR]
Copyright of Nature Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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