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Tytuł pozycji:

Model selection versus model averaging in dose finding studies.

Tytuł :
Model selection versus model averaging in dose finding studies.
Autorzy :
Schorning, Kirsten
Bornkamp, Björn
Bretz, Frank
Dette, Holger
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Temat :
DOSE-effect relationship in pharmacology
OBSTRUCTIVE lung diseases
SAMPLE size (Statistics)
Źródło :
Statistics in Medicine; 9/30/2016, Vol. 35 Issue 22, p4021-4040, 20p
Czasopismo naukowe
A key objective of Phase II dose finding studies in clinical drug development is to adequately characterize the dose response relationship of a new drug. An important decision is then on the choice of a suitable dose response function to support dose selection for the subsequent Phase III studies. In this paper, we compare different approaches for model selection and model averaging using mathematical properties as well as simulations. We review and illustrate asymptotic properties of model selection criteria and investigate their behavior when changing the sample size but keeping the effect size constant. In a simulation study, we investigate how the various approaches perform in realistically chosen settings. Finally, the different methods are illustrated with a recently conducted Phase II dose finding study in patients with chronic obstructive pulmonary disease. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Copyright of Statistics in Medicine is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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