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Tytuł pozycji:

Neutrophil Gelatinase-Associated Lipocalin and its Receptors in Alzheimer's Disease (AD) Brain Regions: Differential Findings in AD with and without Depression.

Tytuł :
Neutrophil Gelatinase-Associated Lipocalin and its Receptors in Alzheimer's Disease (AD) Brain Regions: Differential Findings in AD with and without Depression.
Autorzy :
Dekens, Doortje W.
Naudé, Petrus J. W.
Engelborghs, Sebastiaan
Vermeiren, Yannick
Van Dam, Debby
Voshaar, Richard C. Oude
Eisel, Ulrich L. M.
De Deyn, Peter P.
Oude Voshaar, Richard C
Pokaż więcej
Temat :
ALZHEIMER'S disease
MENTAL depression
LIPOCALINS
MEGALIN
PATHOLOGICAL physiology
BRAIN metabolism
ANALYSIS of variance
CELL receptors
ENZYME-linked immunosorbent assay
PSYCHOLOGICAL tests
DISEASE complications
Źródło :
Journal of Alzheimer's Disease; 2017, Vol. 55 Issue 2, p763-776, 14p
Czasopismo naukowe
Co-existing depression worsens Alzheimer's disease (AD) pathology. Neutrophil gelatinase-associated lipocalin (NGAL) is a newly identified (neuro)inflammatory mediator in the pathophysiologies of both AD and depression. This study aimed to compare NGAL levels in healthy controls, AD without depression (AD-D), and AD with co-existing depression (AD+D) patients. Protein levels of NGAL and its receptors, 24p3R and megalin, were assessed in nine brain regions from healthy controls (n = 19), AD-D (n = 19), and AD+D (n = 21) patients. NGAL levels in AD-D patients were significantly increased in brain regions commonly associated with AD. In the hippocampus, NGAL levels were even further increased in AD+D subjects. Unexpectedly, NGAL levels in the prefrontal cortex of AD+D patients were comparable to those in controls. Megalin levels were increased in BA11 and amygdala of AD+D patients, while no changes in 24p3R were detected. These findings indicate significant differences in neuroimmunological regulation between AD patients with and without co-existing depression. Considering its known effects, elevated NGAL levels might actively promote neuropathological processes in AD with and without depression. [ABSTRACT FROM AUTHOR]
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