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Tytuł:
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Aflibercept plus FOLFIRI in Asian patients with pretreated metastatic colorectal cancer: a randomized Phase III study.
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Autorzy:
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Li, Jin
Xu, Ruihua
Qin, Shukui
Liu, Tianshu
Pan, Hongming
Xu, Jianming
Bi, Feng
Lim, Robert
Zhang, Suzhan
Ba, Yi
Bai, Yuxian
Fan, Nanfeng
Tsuji, Akihito
Yeh, Kun-Huei
Ma, Brigette
Wei, Vivian
Shi, Dongmei
Magherini, Emmanuelle
Shen, Lin
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Temat:
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ANTINEOPLASTIC agents
CAMPTOTHECIN
CELL receptors
COLON tumors
COMPARATIVE studies
FLUOROURACIL
FOLINIC acid
RESEARCH methodology
MEDICAL cooperation
METASTASIS
RECOMBINANT proteins
RECTUM tumors
REOPERATION
RESEARCH
STATISTICAL sampling
TUMOR classification
EVALUATION research
RANDOMIZED controlled trials
TREATMENT effectiveness
KAPLAN-Meier estimator
THERAPEUTICS
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Źródło:
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Future Oncology; 8/17/2018, Vol. 14 Issue 20, p2031-2044, 14p
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Aim: To investigate whether the benefit of combining aflibercept with 5-fluorouracil, folinic acid and irinotecan (FOLFIRI) chemotherapy could be confirmed in patients from the Asia-Pacific region (ClinicalTrials.gov: NCT01661270). Patients & methods: Asian patients with oxaliplatin-pretreated metastatic colorectal cancer were randomized to receive aflibercept or placebo, followed by FOLFIRI. The primary end point was progression-free survival.Results: The intention-to-treat population comprised 332 patients. A clinical supply misallocation resulted in 198/332 (60%) patients receiving at least one cycle of misallocated treatment. Nevertheless, the addition of aflibercept to FOLFIRI was shown to improve progression-free survival (hazard ratio: 0.629; 95% CI: 0.488-0.812). Adverse events were in line with expectations.Conclusion: The beneficial treatment effect associated with the addition of aflibercept to FOLFIRI was confirmed in Asian patients with pretreated metastatic colorectal cancer. [ABSTRACT FROM AUTHOR]
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