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Tytuł pozycji:

ATP-Gated P2X Receptor Channels: Molecular Insights into Functional Roles.

Tytuł :
ATP-Gated P2X Receptor Channels: Molecular Insights into Functional Roles.
Autorzy :
Schmid, Ralf
Evans, Richard J.
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Źródło :
Annual Review of Physiology; Feb2019, Vol. 81, p43-62, 15p
Czasopismo naukowe
In the nervous system, ATP is co-stored in vesicles with classical transmitters and released in a regulated manner. ATP from the intracellular compartment can also exit the cell through hemichannels and following shear stress or membrane damage. In the past 30 years, the action of ATP as an extracellular transmitter at cell-surface receptors has evolved from somewhat of a novelty that was treated with skepticism to purinergic transmission being accepted as having widespread important functional roles mediated by ATP-gated ionotropic P2X receptors (P2XRs). This review focuses on work published in the last five years and provides an overview of (a) structural studies, (b) the molecular basis of channel properties and regulation of P2XRs, and (c) the physiological and pathophysiological roles of ATP acting at defined P2XR subtypes. [ABSTRACT FROM AUTHOR]
Copyright of Annual Review of Physiology is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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