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Title of the item:

Effect of pallidal deep-brain stimulation on articulation rate in dystonia.

Effect of pallidal deep-brain stimulation on articulation rate in dystonia.
Rusz, Jan
Fečíková, Anna
Tykalová, Tereza
Jech, Robert
Subject Terms:
GLOBUS pallidus
DRUG side effects
TREATMENT of dystonia
BASAL ganglia
DEEP brain stimulation
Neurological Sciences; Apr2019, Vol. 40 Issue 4, p869-873, 5p, 1 Chart, 1 Graph
Academic Journal
Pallidal deep-brain stimulation of the internal globus pallidus (GPi-DBS) is an effective treatment for dystonia. However, GPi-DBS may cause important stimulation-induced side effects such as hypokinetic dysarthria, which is particularly manifested by articulation rate abnormalities. However, little data regarding the effect of the location of the electrode and stimulation parameters for pallidal stimulation on articulation rate in dystonia is available. Speech data were acquired from 18 dystonic patients with GPi-DBS and 18 matched healthy controls. Each of dystonic patients was tested twice within 1 day in both the GPi-DBS ON and GPi-DBS OFF stimulation conditions. Compared to healthy controls, the decreased diadochokinetic rate and slower articulation rate in dystonic patients were observed in both stimulation conditions. No significant differences in speech rate measures between stimulation conditions were detected with no relation to contact localization and stimulation intensity. Our findings do not support the use articulation rate as a surrogate marker of stimulation-induced changes to the speech apparatus in dystonia. [ABSTRACT FROM AUTHOR]
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