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Tytuł pozycji:

Ductal carcinoma in situ: to treat or not to treat, that is the question.

Tytuł :
Ductal carcinoma in situ: to treat or not to treat, that is the question.
Autorzy :
van Seijen, Maartje
Lips, Esther H.
Thompson, Alastair M.
Nik-Zainal, Serena
Futreal, Andrew
Hwang, E. Shelley
Verschuur, Ellen
Lane, Joanna
Jonkers, Jos
Rea, Daniel W.
Wesseling, Jelle
PRECISION team
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Źródło :
British Journal of Cancer; Aug2019, Vol. 121 Issue 4, p285-292, 8p, 1 Diagram, 1 Chart
Czasopismo naukowe
Ductal carcinoma in situ (DCIS) now represents 20-25% of all 'breast cancers' consequent upon detection by population-based breast cancer screening programmes. Currently, all DCIS lesions are treated, and treatment comprises either mastectomy or breast-conserving surgery supplemented with radiotherapy. However, most DCIS lesions remain indolent. Difficulty in discerning harmless lesions from potentially invasive ones can lead to overtreatment of this condition in many patients. To counter overtreatment and to transform clinical practice, a global, comprehensive and multidisciplinary collaboration is required. Here we review the incidence of DCIS, the perception of risk for developing invasive breast cancer, the current treatment options and the known molecular aspects of progression. Further research is needed to gain new insights for improved diagnosis and management of DCIS, and this is integrated in the PRECISION (PREvent ductal Carcinoma In Situ Invasive Overtreatment Now) initiative. This international effort will seek to determine which DCISs require treatment and prevent the consequences of overtreatment on the lives of many women affected by DCIS. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Cancer is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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