Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Validity of retrospective occupational exposure estimates of lead and manganese in a case-control study.

Tytuł :
Validity of retrospective occupational exposure estimates of lead and manganese in a case-control study.
Autorzy :
Sauvé, Jean-François
Ramsay, Joemy M.
Locke, Sarah J.
Dopart, Pamela J.
Josse, Pabitra R.
Zaebst, Dennis D.
Albert, Paul S.
Cantor, Kenneth P.
Baris, Dalsu
Jackson, Brian P.
Karagas, Margaret R.
Hosain, G. M. Monawar
Schwenn, Molly
Johnson, Alison
Purdue, Mark P.
Koutros, Stella
Silverman, Debra T.
Friesen, Melissa C.
Hosain, Gm Monawar
Pokaż więcej
Źródło :
Occupational & Environmental Medicine; Sep2019, Vol. 76 Issue 9, p680-687, 8p, 5 Charts
Czasopismo naukowe
Objectives: The validity of surrogate measures of retrospective occupational exposure in population-based epidemiological studies has rarely been evaluated. Using toenail samples as bioindicators of exposure, we assessed whether work tasks and expert assessments of occupational metal exposure obtained from personal interviews were associated with lead and manganese concentrations.Methods: We selected 609 controls from a case-control study of bladder cancer in New England who had held a job for ≥1 year 8-24 months prior to toenail collection. We evaluated associations between toenail metal concentrations and five tasks extracted from occupational questionnaires (grinding, painting, soldering, welding, working near engines) using linear regression models. For 139 subjects, we also evaluated associations between the toenail concentrations and exposure estimates from three experts.Results: We observed a 1.9-fold increase (95% CI 1.4 to 2.5) in toenail lead concentrations with painting and 1.4-fold increase (95% CI 1.1 to 1.7) in manganese concentrations with working around engines and handling fuel. We observed significant trends with increasing frequency of both activities. For lead, significant trends were observed with the ratings from all three experts. Their average ratings showed the strongest association, with subjects rated as possibly or probably exposed to lead having concentrations that were 2.0 and 2.5 times higher, respectively, than in unexposed subjects (ptrend <0.001). Expert estimates were only weakly associated with manganese toenail concentrations.Conclusions: Our findings support the ability of experts to identify broad contrasts in previous occupational exposure to lead. The stronger associations with task frequency and expert assessments support using refined exposure characterisation whenever possible. [ABSTRACT FROM AUTHOR]
Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies