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Tytuł pozycji:

Handheld projective imaging device for near-infrared fluorescence imaging and intraoperative guidance of sentinel lymph node resection.

Tytuł:
Handheld projective imaging device for near-infrared fluorescence imaging and intraoperative guidance of sentinel lymph node resection.
Autorzy:
Chenmeng Li
Peng Liu
Pengfei Shao
Jing Pei
Yingrui Li
Pawlik, Timothy M.
Martin, Edward W.
Xu, Ronald X.
Temat:
SENTINEL lymph nodes
PROJECTORS
LYMPH node cancer
FLUORESCENCE
LYMPHANGIOGRAPHY
SINGLE-board computers
LIGHT sources
AUTORADIOGRAPHY
Źródło:
Journal of Biomedical Optics; Aug2019, Vol. 24 Issue 8, p1-4, 4p
Czasopismo naukowe
We propose a handheld projective imaging device for orthotopic projection of near-infrared fluorescence images onto target biological tissue at visible wavelengths without any additional visual aid. The device integrates a laser diode light source module, a camera module, a projector, an ultrasonic distance sensor, a Raspberry Pi single-board computer, and a battery module in a rugged handheld unit. It is calibrated at the detected working distance for seamless coregistration between fluorescence emission and projective imaging at the target tissue site. The proposed device is able to achieve a projection resolution higher than 314 μm and a planar projection bias less than 1 mm at a projection field of view of 58 × 108 mm2 and a working distance of 27 cm. Technical feasibility for projective imaging is verified in an ex vivo model of chicken breast tissue using indocyanine green as a fluorescence agent. Clinical utility for image-guided surgery is demonstrated in a clinical trial where sentinel lymph nodes in breast cancer patients are identified and resected under the guidance of projective imaging. Our ex vivo and in vivo experiments imply the clinical utility of deploying the proposed device for imageguided surgical interventions in resource-limited settings. [ABSTRACT FROM AUTHOR]
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