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Tytuł pozycji:

S100A14 在乳腺癌不同分子亚型中表达的临床病理研究. (Chinese)

Tytuł :
S100A14 在乳腺癌不同分子亚型中表达的临床病理研究. (Chinese)
Autorzy :
谭传斌
李晶
黄三钱
谭平萍
曾亮
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Temat :
BREAST metastasis
BREAST cancer prognosis
LIVER metastasis
CANCER hospitals
BREAST cancer
AXILLARY lymph node dissection
Alternatywny tytuł :
Clinicopathological Study of S100A14 Expression in Different Molecular Subtype of Breast Cancer. (English)
Źródło :
Progress in Modern Biomedicine; Jul2019, Vol. 19 Issue 13, p2528-2510, 7p
Terminy geograficzne :
HUNAN Sheng (China)
Abstract (English) :
Objective: Expression and clinicopathological significance of S100 calcium binding protein A14(S100A14) in different molecular subtypes of breast cancer were explored to provide reference for identifying new molecular typing markers. Methods:Breast cancer tissues were taken cases for radical mastectomy patients from January 16, 2013 to 22 May 2014 at the Cancer Hospital Affiliated to the Xiangya Medical College of Central South University & the Cancer Hospital of Hunan province. Using immunohistochemistry to detect the expression of S100A14 in 254 breast cancer tissues, with emphasis on differences expression of the protein in different molecular subtypes of breast carcinoma and its correlation with clinicopathological factors, Kaplan-Meier analysis was applied for the relationship between S100 A14 expression and prognosis of patients with breast cancer. Results: The positive expression of S100 A14 in four molecular subtypes of ER+/PR+/HER2+, ER+/PR+/HER2-, ER-/PR-/HER2+ and ER-/PR-/HER2-breast cancer was 38.5%, 47.1%, 75.5%, 80%, respectively. The expression of the 4 groups was the highest in the ER-/PR-/HER2-type and the lowest in the ER+/PR+/HER2+ type, and the difference between the 4 groups was significant(x=6.768, P=0.013), and S100A4 expression has a negative correlation with postoperative pulmonary metastasis(r=-0.272, P=0.044). Conclusion: The expression of S100A14 in breast cancer with different molecular subtypes is different, and its high expression is associated with metastasis or recurrence of breast cancer with different molecular types. It may be used as a candidate marker for molecular typing of breast cancer. [ABSTRACT FROM AUTHOR]
Czasopismo naukowe
Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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