Effects of Bispectral Index-controlled Use of Magnesium on Propofol Consumption and Sedation Level in Patients Undergoing Colonoscopy.

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Tytuł:: Effects of Bispectral Index-controlled Use of Magnesium on Propofol Consumption and Sedation Level in Patients Undergoing Colonoscopy.
Autorzy:: YOLDAS, Hamit
YILDIZ, Isa
KARAGOZ, Ibrahim
SIT, Mustafa
OGUN, Muhammed Nur
DEMIRHAN, Abdullah
BILGI, Murat
Temat:: PROPOFOL
MAGNESIUM
MAGNESIUM group
DRUG utilization
MAGNESIUM sulfate
Alternatywny tytuł:: Kolonoskopi Uygulanan Hastalarda, Bispektral İndeks Kontrollü, Magnezyum Kullanımının Propofol Tüketimi ve Sedasyon Düzeyine Etkisi. (Turkish)
Źródło:: Medeniyet Medical Journal; 2019, Vol. 34 Issue 4, p380-386, 7p
Abstract (English):: Objective: The aim of this study is to investigate the effects of bispectral index-controlled use of magnesium on propofol consumption, periprocedural hemodynamic response and patient comfort. Material: A total of 60 patients were enrolled in the study. In Group 1 (magnesium), a single dose 50 mg/kg magnesium sulfate diluted with 100 mL 0.9% NaCl was administered 10 minutes before the beginning of the procedure. Initially bolus dose of 0.5 mg/kg propofol was applied. The maintenance dose of propofol was 60 mcg/kg/min. During the procedure, the propofol infusion was increased by titration until the bispectral index (BIS) value of 70 was achieved. In Group 2 (saline), 100 ml 0.9% NaCl was administered 10 minutes before the beginning of the procedure. The bolus and maintenance doses of propofol, and target BIS values were the same as those in Group 1. Results: When BIS values were compared between the groups, the initial BIS values in the magnesium group (Group 1) were significantly higher than those of the saline group (Group 2) (p<0.05). The time to reach BIS 70 was significantly shorter in the magnesium group (p<0.05). Propofol consumption was greater in Group 2 than in Group 1 (p<0.05). The time to reach BIS 70 was significantly shorter in Group 1 (p<0.05). No significant difference was found between the groups in terms of patient- and endoscopist-satisfaction (p<0.05). Conclusion: The use of magnesium in addition to propofol may be an efficient and reliable option to reduce the drug consumption during colonoscopic interventions. [ABSTRACT FROM AUTHOR]
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