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Tytuł:
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Fasting Blood Glucose and HbA1c Correlate With Severity of Coronary Artery Disease in Elective PCI Patients With HbA1c 5.7% to 6.4%.
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Autorzy:
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Yang, Jie
Zhou, Yujie
Zhang, Tingyu
Lin, Xuze
Ma, Xiaoteng
Wang, Zhijian
Liu, Yuyang
Shi, Dongmei
Zhou, Zhiming
Zhao, Yingxin
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Temat:
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CORONARY heart disease surgery
BLOOD sugar
CONFIDENCE intervals
GLYCOSYLATED hemoglobin
PATIENTS
PREDIABETIC state
SURGERY
ELECTIVE surgery
MULTIPLE regression analysis
SEVERITY of illness index
PREPROCEDURAL fasting
DESCRIPTIVE statistics
CORONARY angiography
ODDS ratio
PERCUTANEOUS coronary intervention
EVALUATION
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Źródło:
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Angiology; Feb2020, Vol. 71 Issue 2, p167-174, 8p
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Diabetes mellitus, and even prediabetes, has been shown to be independently associated with cardiovascular disease. Our study explored whether the combination of glycosylated hemoglobin (HbA1c) and fasting blood glucose (FBG) can better assess the severity of coronary heart disease (CHD) in elective percutaneous coronary intervention (PCI) patients. We consecutively enrolled 1006 prediabetic patients with HbA1c 5.7% to 6.4% who underwent elective PCI. Patients were divided into 2 groups: a normal fasting glucose (NFG) group (FBG <6.1 mmol/L) and an impaired fasting glucose (IFG) group (6.1 ≤FBG<7.0 mmol/L) with defined values. Baseline characteristics and angiography data of the 2 groups were compared. The prevalence of 3-vessel disease (P =.002), the GENSINI (the score is named after a professor) score (P =.002), and the SYNTAX (SYNergy between PCI with TAXUS™ and Cardiac Surgery) score (P =.002) of the IFG group was significantly higher compared to the NFG group. After multiple regression analysis, FBG was found to be independently associated with prevalence of 3-vessel disease (adjusted odds ratio: 1.62; 95% confidence interval: 1.21-2.36; P =.013), the GENSINI score (standardized β =.138, P =.008), and the SYNTAX score (standardized β =.145, P =.005). In addition, HbA1c was independently associated with the prevalence of 3-vessel disease, the GENSINI, score, and the SYNTAX score (P <.05). Both FBG and HbA1c are independently correlated with the severity of CHD in prediabetic patients with HbA1c 5.7% to 6.4%. [ABSTRACT FROM AUTHOR]
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