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Tytuł pozycji:

Cardioprotective Efficacy of Coriandrum sativum (L.) Seed Extract in Heart Failure Rats Through Modulation of Endothelin Receptors and Antioxidant Potential.

Tytuł :
Cardioprotective Efficacy of Coriandrum sativum (L.) Seed Extract in Heart Failure Rats Through Modulation of Endothelin Receptors and Antioxidant Potential.
Autorzy :
Dhyani, Neha
Parveen, Adila
Siddiqi, Aisha
Hussain, M. Ejaz
Fahim, Mohammad
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Temat :
LIPID analysis
ANIMAL experimentation
ANTIOXIDANTS
CARDIOTONIC agents
ENDOTHELINS
LEFT heart ventricle
HEART physiology
HEART failure
HEMODYNAMICS
LIPID peroxidation (Biology)
RATS
SEEDS
PLANT extracts
SIMVASTATIN
CHEMICAL inhibitors
PHARMACODYNAMICS
Źródło :
Journal of Dietary Supplements; 2020, Vol. 17 Issue 1, p13-26, 14p
Czasopismo naukowe
The present study aimed to evaluate the therapeutic and prophylactic potential of Coriandrum sativum extract in isoproterenol-induced heart failure (HF) in Wistar rats. Two weeks after the isoproterenol administration, rats developed severe impairment in left ventricular functions, reduced baroreflex sensitivity, and significant alteration in hemodynamic parameters and lipid profile. HF rats also exhibited enhanced lipid peroxidation and increased expression of endothelin receptors (ETA and ETB). Therapeutic and prophylactic treatment with C. sativum extract significantly (p <.05) improved the left ventricular functions and hemodynamic parameters and increased baroreflex sensitivity. It also inhibited lipid peroxidation, improved lipid profile, and downregulated the expression of endothelin receptors. Simvastatin treatment showed a similar cardioprotective effect. Our results suggest that C. sativum extract provides significant protection from heart failure possibly due to its ability to improve left ventricular functions and baroreflex sensitivity, attenuate lipid peroxidation, and modulate the expression of endothelin receptors. [ABSTRACT FROM AUTHOR]
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