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Title of the item:

MULTIVARIATE CALIBRATION METHOD FOR SIMULTANEOUS ESTIMATION OF FLUOCORTOLONE CAPROATE, FLUOCORTOLONE PIVALATE AND CINCHOCAINE HCL IN SUPPOSITORY.

Title :
MULTIVARIATE CALIBRATION METHOD FOR SIMULTANEOUS ESTIMATION OF FLUOCORTOLONE CAPROATE, FLUOCORTOLONE PIVALATE AND CINCHOCAINE HCL IN SUPPOSITORY.
Authors :
DÖNMEZ, ÖZLEM AKSU
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Subject Terms :
SUPPOSITORIES
FACTORIAL experiment designs
CALIBRATION
ABSORPTION spectra
Source :
Studia Universitatis Babes-Bolyai, Chemia; Dec2019, Vol. 64 Issue 4, p121-130, 10p
Company/Entity :
UNITED States. Federal Communications Commission
Academic Journal
In this paper, the simultaneous quantitative assay of Fluocortolone caproate (FCC), Fluocortolone pivalate (FCP) and Cinchocaine HCl (CIN) in suppository has been reported as a simple alternative analytical method. A partial least squares (PLS-2) regression was used for resolution of the overlapped spectrophotometric signals from mixtures of the three drugs. A calibration set containing FCC, FCP and CIN was constructed by using 33 full factorial design in the concentration range of 4.5-8.5, 5-7 and 8-12 μg/mL, respectively. Absorption spectra were recorded in the range 240-350 nm. To check the quality of the proposed method, it was applied to the determination of these compounds in synthetic mixtures and pharmaceutical formulation, suppository. The PLS-2 method yielded recoveries ranging from 91 to 106%. The results compared well with those from the reported HPLC method. [ABSTRACT FROM AUTHOR]
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