Twenty-nine patients with asthma and aspirin-sensitivity were studied in an attempt to induce tolerance to aspirin (ASA). Starting wich the smallest .ASA doses eliciting bronchial obstruction (threshold doses) we doubled the doses on subsequent days and finally achieved good tolerance of 600 mg ,ASA per day in 27 patients. It was more difficult to achieve tolerance in patients with low ASA-thresholds than in patients with high ones. Daily ASA administration led to prolongation of the refractory state but when the intervals between consecutive doses were increased, aspirin bypersensitivity recurred. The pause sufficient for a recurrence of sensitivity to ASA was measured in to patients and ranged from 24 h to M days. Twelve patients challenged with indomethacin after ASA-desensitisation showed good drug tolerance. [ABSTRACT FROM AUTHOR]
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